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Previous Volume 334:759-762 March 21, 1996 Number 12 Next

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ABSTRACT

Background Previous studies have suggested that hyperhomocysteinemia may be a risk factor for venous thrombosis. To assess the risk of venous thrombosis associated with hyperhomocysteinemia, we studied plasma homocysteine levels in patients with a first episode of deep-vein thrombosis and in normal control subjects.

Methods We measured plasma homocysteine levels in 269 patients with a first, objectively diagnosed episode of deep-vein thrombosis and in 269 healthy controls matched to the patients according to age and sex. Hyperhomocysteinemia was defined as a plasma homocysteine level above the 95th percentile in the control group (18.5 µmol per liter).

Results Of the 269 patients, 28 (10 percent) had plasma homocysteine levels above the 95th percentile for the controls, as compared with 13 of the controls (matched odds ratio, 2.5; 95 percent confidence interval, 1.2 to 5.2). The association between elevated homocysteine levels and venous thrombosis was stronger among women than among men and increased with age. The exclusion of subjects with other established risk factors for thrombosis (e.g., a deficiency of protein C, protein S, or antithrombin; resistance to activated protein C; pregnancy or recent childbirth; or oral-contraceptive use) did not materially affect the risk estimates.

Conclusions High plasma homocysteine levels are a risk factor for deep-vein thrombosis in the general population.

Source Information

From the Department of Hematology, Municipal Hospital Leyenburg, The Hague (M.H., G.M.J.B.); the Departments of Clinical Epidemiology (T.K., J.P.V., F.R.R.) and Hematology (E.B., P.H.R., F.R.R.), University Hospital, Leiden; and the Laboratory of Pediatrics and Neurology, Department of Pediatrics, University Hospital, Nijmegen (H.J.B.) — all in the Netherlands.

Address reprint requests to Dr. den Heijer at the Department of Hematology, Municipal Hospital Leyenburg, P.O. Box 40551, 2504 LN The Hague, the Netherlands.

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Hyperhomocysteinemia as a Risk Factor for Deep-Vein Thrombosis
Cattaneo M., Martinelli I., Mannucci P. M., Jacobson M. W., den Heijer M., Blom H. J., Rosendaal F. R.
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N Engl J Med 1996; 335:974-976, Sep 26, 1996. Correspondence

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