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Review Article
Mechanisms of Disease
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Volume 334:770-776 March 21, 1996 Number 12
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Intracellular Pathogenesis of Listeriosis
Frederick S. Southwick, M.D., and Daniel L. Purich, Ph.D.

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Listeria monocytogenes, an aerobic and facultatively anaerobic gram-positive bacillus, can be readily isolated from soil, dust, fertilizer, sewage, stream water, plants, and even processed foods stored at 4°C. The organism is also present in the intestinal tract of numerous mammals, birds, fish, and crustaceans. Recent epidemiologic studies provide strong evidence that both sporadic and common-source outbreaks of listeriosis are foodborne.1,2

Despite the pervasiveness of L. monocytogenes in the environment, the annual incidence of listeriosis is only 0.7 case per 100,000. However, the annual rate of infection is 3 times higher among persons over the age of 70 years (2.1 . . . [Full Text of this Article]

Intracellular Survival and Spread of Listeria in Host Cells

Actin Cytoskeleton Proteins

Intracellular Actin-Based Motility of Listeria

Clinical Consequences of the Life Cycle of Listeria

Epidemiology

Meningitis and Meningoencephalitis

Granulomatosis Infantiseptica

Antibiotic Treatment

Conclusions


Source Information

From the Division of Infectious Diseases, Department of Medicine (F.S.S.), and the Department of Biochemistry and Molecular Biology (F.S.S., D.L.P.), University of Florida College of Medicine, Gainesville.

Address reprint requests to Dr. Southwick at the Division of Infectious Diseases, Box 100277, University of Florida College of Medicine, Gainesville, FL 32610-0277.

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