Non-insulin-dependent diabetes mellitus (NIDDM), the commonestform of diabetes, affects approximately 5 percent of the populationof the United States. Although the pathophysiology of this conditionhas not been fully characterized and the nature of the primarydefect is controversial, the results of recent studies provideinsights into its basic causes. Here, we review these studiesand suggest how insulin resistance and genetically programmedpancreatic beta-cell dysfunction may interact in susceptiblepersons to cause diabetes.
Insulin Resistance
Insulin resistance is a diminished ability of insulin to exertits biologic action across a broad range of concentrations.Unless persons with insulin resistance secrete . . . [Full Text of this Article]
Insulin Resistance and the Risk of Niddm
The Beta-Cell Response to Insulin Resistance
The Role of Abnormal Beta-Cell Function in the Evolution of Niddm
Studies in Animals
Studies in Humans
Persons with Overt Diabetes
Persons with Impaired Glucose Tolerance
Persons with Normal Plasma Glucose Concentrations
Genetics of Classic Niddm
Discussion
Source Information
From the Departments of Medicine (K.S.P., J.S., G.I.B.), Biochemistry (G.I.B.), and Molecular Biology (G.I.B.) and the Howard Hughes Medical Institute, University of Chicago and Pritzker School of Medicine, Chicago.
Address reprint requests to Dr. Polonsky at the University of Chicago, Dept. of Medicine, 5841 S. Maryland Ave., MC 1027, Chicago, IL 60637.
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