The treatment of Hodgkin's disease is a model of successfultherapy for childhood cancer, with cure rates of over 90 percentexpected from chemotherapy regimens and low-dose radiation (15to 25 Gy) to involved regions.1 The current therapy evolvedto minimize previously recognized late effects of treatment,such as growth retardation and secondary malignant tumors. Inthis issue of the Journal, Bhatia et al.,2 representing theLate Effects Study Group, report that second cancers developed18 times more often in patients who received treatment for Hodgkin'sdisease before the age of 16 years than would be expected inthe general . . . [Full Text of this Article]
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