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Correspondence
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Volume 334:799-800 March 21, 1996 Number 12
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Goal-Oriented Hemodynamic Therapy

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 by Hinds, C.
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 by Gattinoni, L.
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To the Editor: In their prospective, multicenter trial, Gattinoni and colleagues (Oct. 19 issue)1 evaluated the effects of increasing the cardiac index to a supranormal level or increasing mixed venous oxygen saturation to a normal level on the survival of critically ill patients. These resuscitative end points have been associated with increased survival in several prospective studies of critically ill patients.2,3,4 A popular explanation for this favorable association is that the imbalance between oxygen supply and demand in critically ill patients is minimal or absent when a supranormal level of oxygen delivery or a normal level of mixed venous oxygen . . . [Full Text of this Article]

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