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Previous Volume 334:904-906 April 4, 1996 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The ability to remove or alter with precision a single one of the thousands of genes in the body and to transmit this mutation to all subsequent progeny was a science-fiction dream only a few years ago. But today this technique is part of a routine procedure for creating animal models that can be used to study the pathophysiology and therapy of diseases in humans.

In general, mutations that cause a gain of function produce disease even when they occur in only one of a gene's two alleles; for example, the oncogenic mutations that cause abnormal cell proliferation. In a . . . [Full Text of this Article]

Source Information

From the Division of Endocrinology, Children's Hospital, Harvard Medical School, Boston.

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