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Previous Volume 334:920-921 April 4, 1996 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Folkman's article on angiogenesis (Dec. 28 issue)¹ focused on clinical applications, with particular emphasis on the treatment of cancer. There is evidence that angiogenesis is indeed a factor in the progression of human carcinoma, but the extent of its role is in question.² Although an intratumoral lymphatic system is usually not well developed in solid tumors, an elaborate system of lymphatic and prelymphatic channels in close proximity to the primary cancer and invasive areas has been reported in breast cancer.³ It is therefore important to consider the possible impact of lymphagenesis (lymphatic-vessel formation) on the growth and . . . [Full Text of this Article]

References

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• Birner, P., Obermair, A., Schindl, M., Kowalski, H., Breitenecker, G., Oberhuber, G. (2001). Selective Immunohistochemical Staining of Blood and Lymphatic Vessels Reveals Independent Prognostic Influence of Blood and Lymphatic Vessel Invasion in Early-Stage Cervical Cancer. Clin. Cancer Res. 7: 93-97 [Abstract] [Full Text]  
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