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Previous Volume 334:989 April 11, 1996 Number 15 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: It is useful to be reminded of the hypothesis that Fisher et al. were testing when they compared lumpectomy alone with lumpectomy plus radiation in the NSABP Protocol B-06 trial (Nov. 30 issue).¹ Fisher et al. articulate two divergent hypotheses of tumor biology: "Halstedean" and "alternative."² The Halstedean hypothesis³ argues that breast cancer is an orderly disease, spreading in a contiguous fashion from the primary site through the lymphatic vessels to the lymph nodes and then to distant sites. Appropriate treatment would thus emphasize early and complete eradication of the primary tumor, draining lymphatic vessels and lymph . . . [Full Text of this Article]

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