FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 334:1084-1089 April 25, 1996 Number 17 Next

	Full Text PDF Letters Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

ABSTRACT

Background The clinical benefit of coronary-artery stenting performed in conjunction with coronary angioplasty is limited by the risk of thrombotic occlusion of the stent as well as hemorrhagic and vascular complications of intensive anticoagulation. We compared antiplatelet therapy with conventional anticoagulant therapy with respect to clinical outcomes 30 days after coronary-artery stenting.

Methods After successful placement of Palmaz–Schatz coronary-artery stents, 257 patients were randomly assigned to receive antiplatelet therapy (ticlopidine plus aspirin) and 260 to receive anticoagulant therapy (intravenous heparin, phenprocoumon, and aspirin). The primary cardiac end point was a composite measure reflecting death from cardiac causes or the occurrence of myocardial infarction, aortocoronary bypass surgery, or repeated angioplasty. The primary noncardiac end point comprised death from noncardiac causes, cerebrovascular accident, severe hemorrhage, and peripheral vascular events.

Results Of the patients assigned to antiplatelet therapy, 1.6 percent reached a primary cardiac end point, as did 6.2 percent of those assigned to anticoagulant therapy (relative risk, 0.25; 95 percent confidence interval, 0.06 to 0.77). With antiplatelet therapy, there was an 82 percent lower risk of myocardial infarction than in the anticoagulant-therapy group, and a 78 percent lower need for repeated interventions. Occlusion of the stented vessel occurred in 0.8 percent of the antiplatelet-therapy group and in 5.4 percent of the anticoagulant-therapy group (relative risk, 0.14; 95 percent confidence interval, 0.02 to 0.62). A primary noncardiac end point was reached by 1.2 percent of the antiplatelet-therapy group and 12.3 percent of the anticoagulant-therapy group (relative risk, 0.09; 95 percent confidence interval, 0.02 to 0.31). Hemorrhagic complications occurred only in the anticoagulant-therapy group (in 6.5 percent). An 87 percent reduction in the risk of peripheral vascular events was observed with antiplatelet therapy.

Conclusions As compared with conventional anticoagulant therapy, combined antiplatelet therapy after the placement of coronary-artery stents reduces the incidence of both cardiac events and hemorrhagic and vascular complications.

Source Information

From the 1. Medizinische Klinik (A.S., F.-J.N., A.K., H.S., R.B., M.H., H.W., E.-M.Z.-R., G.R., E.A., C.S.), and the Institut für Medizinische Statistik und Epidemiologie (K.U.), Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

Address reprint requests to Dr. Schömig at the 1. Medi-zinische Klinik der Technischen Universität München, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675 Munich, Germany.

Full Text of this Article

Related Letters:

Antiplatelet and Anticoagulant Therapy after Coronary-Artery Stenting
Schöneberger A. A., Schmidt K., Cequier A., Sabaté M., Esplugas E., Neumann F.-J., Walter H., Schömig A.
Extract | Full Text  
N Engl J Med 1996; 335:1160-1161, Oct 10, 1996. Correspondence

DNA Testing to Refute a Diagnosis of Cancer
Gelmann E. P., Lack E.
Extract | Full Text  
N Engl J Med 1997; 337:1245-1247, Oct 23, 1997. Correspondence

This article has been cited by other articles:

• Becker, R. C., Scheiman, J., Dauerman, H. L., Spencer, F., Rao, S., Sabatine, M., Johnson, D. A., Chan, F., Abraham, N. S., Quigley, E. M.M., in collaboration with the American College of Card, (2009). Management of Platelet-Directed Pharmacotherapy in Patients With Atherosclerotic Coronary Artery Disease Undergoing Elective Endoscopic Gastrointestinal Procedures. J Am Coll Cardiol 54: 2261-2276 [Abstract] [Full Text]  
• LAZAR, L. D., LINCOFF, A. M. (2009). Prasugrel for acute coronary syndromes: Faster, more potent, but higher bleeding risk. Cleveland Clinic Journal of Medicine 76: 707-714 [Abstract] [Full Text]  
• Schulz, S., Schuster, T., Mehilli, J., Byrne, R. A., Ellert, J., Massberg, S., Goedel, J., Bruskina, O., Ulm, K., Schomig, A., Kastrati, A. (2009). Stent thrombosis after drug-eluting stent implantation: incidence, timing, and relation to discontinuation of clopidogrel therapy over a 4-year period. Eur Heart J 30: 2714-2721 [Abstract] [Full Text]  
• Sambola, A, Ferreira-Gonzalez, I, Angel, J, Alfonso, F, Maristany, J, Rodriguez, O, Bueno, H, Lopez-Minguez, J R, Zueco, J, Fernandez-Aviles, F, Roman, A S., Prendergast, B, Mainar, V, Garcia-Dorado, D, Tornos, P (2009). Therapeutic strategies after coronary stenting in chronically anticoagulated patients: the MUSICA study. Heart 95: 1483-1488 [Abstract] [Full Text]  
• Schomig, A., Sarafoff, N., Seyfarth, M. (2009). Triple antithrombotic management after stent implantation: when and how?. Heart 95: 1280-1285 [Full Text]  
• Lokhandwala, J. O., Best, P. J.M., Butterfield, J. H., Skelding, K. A., Scott, T., Blankenship, J. C., Buckley, J. W., Berger, P. B. (2009). Frequency of Allergic or Hematologic Adverse Reactions to Ticlopidine Among Patients With Allergic or Hematologic Adverse Reactions to Clopidogrel. Circ Cardiovasc Interv 2: 348-351 [Abstract] [Full Text]  
• Bonello, L, De Labriolle, A, Scheinowitz, M, Lemesle, G, Roy, P, Steinberg, D H, Pinto Slottow, T L, Pakala, R, Pichard, A D, Barragan, P, Camoin-Jau, L, Dignat-George, F, Paganelli, F, Waksman, R (2009). Emergence of the concept of platelet reactivity monitoring of response to thienopyridines. Heart 95: 1214-1219 [Abstract] [Full Text]  
• Holmes, D. R. Jr, Kereiakes, D. J., Kleiman, N. S., Moliterno, D. J., Patti, G., Grines, C. L. (2009). Combining Antiplatelet and Anticoagulant Therapies.. J Am Coll Cardiol 54: 95-109 [Abstract] [Full Text]  
• Gao, C., Ren, C., Li, D., Li, L. (2009). Clopidogrel and aspirin versus clopidogrel alone on graft patency after coronary artery bypass grafting.. Ann. Thorac. Surg. 88: 59-62 [Abstract] [Full Text]  
• Marin, F., Kirchhof, P., Lip, G. Y.H. (2009). Antithrombotic therapy use for patients with atrial fibrillation undergoing percutaneous coronary intervention: new data in an area of limited evidence. Europace 11: 842-843 [Full Text]  
• Hamm, C. W. (2009). Bleeding management and pharmacological strategy in primary percutaneous coronary intervention. Eur Heart J Suppl 11: C9-C12 [Abstract] [Full Text]  
• Mehran, R., Stone, G. W. (2009). New paradigms of care for STEMI focusing on mortality and attributable death analysis: what do device and drug trials teach us?. Eur Heart J Suppl 11: C4-C8 [Abstract] [Full Text]  
• Mehilli, J., Kastrati, A., Schulz, S., Frungel, S., Nekolla, S. G., Moshage, W., Dotzer, F., Huber, K., Pache, J., Dirschinger, J., Seyfarth, M., Martinoff, S., Schwaiger, M., Schomig, A., for the Bavarian Reperfusion Alternatives Evaluati, (2009). Abciximab in Patients With Acute ST-Segment-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention After Clopidogrel Loading: A Randomized Double-Blind Trial. Circulation 119: 1933-1940 [Abstract] [Full Text]  
• Steinhubl, S. R., Berger, P. B. (2009). Aspirin following PCI: too much of a good thing?. Eur Heart J 30: 882-884 [Full Text]  
• Kimura, T., Morimoto, T., Nakagawa, Y., Tamura, T., Kadota, K., Yasumoto, H., Nishikawa, H., Hiasa, Y., Muramatsu, T., Meguro, T., Inoue, N., Honda, H., Hayashi, Y., Miyazaki, S., Oshima, S., Honda, T., Shiode, N., Namura, M., Sone, T., Nobuyoshi, M., Kita, T., Mitsudo, K., for the j-Cypher Registry Investigators, (2009). Antiplatelet Therapy and Stent Thrombosis After Sirolimus-Eluting Stent Implantation. Circulation 119: 987-995 [Abstract] [Full Text]  
• Maksimowicz-McKinnon, K., Selzer, F., Manzi, S., Kip, K. E., Mulukutla, S. R., Marroquin, O. C., Smitherman, T. C., Kuller, L. H., Williams, D. O., Wasko, M. C. M. (2008). Poor 1-Year Outcomes After Percutaneous Coronary Interventions in Systemic Lupus Erythematosus: Report From the National Heart, Lung, and Blood Institute Dynamic Registry. Circ Cardiovasc Interv 1: 201-208 [Abstract] [Full Text]  
• Roy, P., Steinberg, D. H., Sushinsky, S. J., Okabe, T., Pinto Slottow, T. L., Kaneshige, K., Xue, Z., Satler, L. F., Kent, K. M., Suddath, W. O., Pichard, A. D., Weissman, N. J., Lindsay, J., Waksman, R. (2008). The potential clinical utility of intravascular ultrasound guidance in patients undergoing percutaneous coronary intervention with drug-eluting stents. Eur Heart J 29: 1851-1857 [Abstract] [Full Text]  
• Newsome, L. T., Kutcher, M. A., Royster, R. L. (2008). Coronary Artery Stents: Part I. Evolution of Percutaneous Coronary Intervention. Anesth. Analg. 107: 552-569 [Abstract] [Full Text]  
• Stone, G. W. (2008). Angioplasty Strategies in ST-Segment-Elevation Myocardial Infarction: Part I: Primary Percutaneous Coronary Intervention. Circulation 118: 538-551 [Full Text]  
• Yano, Y., Ohmori, T., Hoshide, S., Madoiwa, S., Yamamoto, K., Katsuki, T., Mitsuhashi, T., Mimuro, J., Shimada, K., Kario, K., Sakata, Y. (2008). Determinants of thrombin generation, fibrinolytic activity, and endothelial dysfunction in patients on dual antiplatelet therapy: involvement of factors other than platelet aggregability in Virchow's triad. Eur Heart J 29: 1729-1738 [Abstract] [Full Text]  
• Nappi, J. (2008). Benefits and limitations of current antiplatelet therapies. Am J Health Syst Pharm 65: S5-S10 [Abstract] [Full Text]  
• Widimsky, P., Motovska, Z., Simek, S., Kala, P., Pudil, R., Holm, F., Petr, R., Bilkova, D., Skalicka, H., Kuchynka, P., Poloczek, M., Miklik, R., Maly, M., Aschermann, M., on behalf of the PRAGUE-8 trial Investigators, (2008). Clopidogrel pre-treatment in stable angina: for all patients >6 h before elective coronary angiography or only for angiographically selected patients a few minutes before PCI? A randomized multicentre trial PRAGUE-8. Eur Heart J 29: 1495-1503 [Abstract] [Full Text]  
• Sibbing, D., Busch, G., Braun, S., Jawansky, S., Schomig, A., Kastrati, A., Ott, I., von Beckerath, N. (2008). Impact of bivalirudin or unfractionated heparin on platelet aggregation in patients pretreated with 600 mg clopidogrel undergoing elective percutaneous coronary intervention. Eur Heart J 29: 1504-1509 [Abstract] [Full Text]  
• Harrington, R. A., Becker, R. C., Cannon, C. P., Gutterman, D., Lincoff, A. M., Popma, J. J., Steg, G., Guyatt, G. H., Goodman, S. G. (2008). Antithrombotic Therapy for Non-ST-Segment Elevation Acute Coronary Syndromes: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 133: 670S-707S [Abstract] [Full Text]  
• Stone, G. W., Witzenbichler, B., Guagliumi, G., Peruga, J. Z., Brodie, B. R., Dudek, D., Kornowski, R., Hartmann, F., Gersh, B. J., Pocock, S. J., Dangas, G., Wong, S. C., Kirtane, A. J., Parise, H., Mehran, R., the HORIZONS-AMI Trial Investigators, (2008). Bivalirudin during Primary PCI in Acute Myocardial Infarction. NEJM 358: 2218-2230 [Abstract] [Full Text]  
• Aradi, D., Konyi, A., Palinkas, L., Berki, T., Pinter, T., Tahin, T., Horvath, I., Papp, L., Komocsi, A. (2008). Thienopyridine Therapy Influences Late Outcome After Coronary Stent Implantation. ANGIOLOGY 59: 172-178 [Abstract]  
• Price, M. J., Endemann, S., Gollapudi, R. R., Valencia, R., Stinis, C. T., Levisay, J. P., Ernst, A., Sawhney, N. S., Schatz, R. A., Teirstein, P. S. (2008). Prognostic significance of post-clopidogrel platelet reactivity assessed by a point-of-care assay on thrombotic events after drug-eluting stent implantation. Eur Heart J 29: 992-1000 [Abstract] [Full Text]  
• Kereiakes, D. J., Gurbel, P. A. (2008). Peri-Procedural Platelet Function and Platelet Inhibition in Percutaneous Coronary Intervention. J Am Coll Cardiol Intv 1: 111-121 [Abstract] [Full Text]  
• Sheehy, O. MSc, LeLorier, J. MD PhD, Rinfret, S. MD MSc (2008). Restrictive access to clopidogrel and mortality following coronary stent implantation. CMAJ 178: 413-420 [Abstract] [Full Text]  
• Wilson, J. M., Willerson, J. T. (2008). Myocardial Revascularization with Percutaneous Devices. Card Surg Adult 3: 573-598 [Full Text]  
• Bode, C., Huber, K. (2008). Antiplatelet therapy in percutaneous coronary intervention. Eur Heart J Suppl 10: A13-A20 [Abstract] [Full Text]  
• Singh, S., Arora, R., Khraisat, A., Handa, K., Bahekar, A., Trivedi, A., Khosla, S. (2007). Increased Incidence of In-Stent Thrombosis Related to Cocaine Use: Case Series and Review of Literature. J CARDIOVASC PHARMACOL THER 12: 298-303 [Abstract]  
• Simon, D. I., Schmaier, A. H. (2007). Sweet and Sticky: Diabetic Platelets, Enhanced Reactivity, and Cardiovascular Risk. J Am Coll Cardiol 50: 1548-1550 [Full Text]  
• von Beckerath, N., Kastrati, A., Wieczorek, A., Pogatsa-Murray, G., Sibbing, D., Graf, I., Schomig, A. (2007). A double-blind, randomized study on platelet aggregation in patients treated with a daily dose of 150 or 75 mg of clopidogrel for 30 days. Eur Heart J 28: 1814-1819 [Abstract] [Full Text]  
• Jaffe, R., Strauss, B. H. (2007). Late and Very Late Thrombosis of Drug-Eluting Stents: Evolving Concepts and Perspectives. J Am Coll Cardiol 50: 119-127 [Abstract] [Full Text]  
• Nguyen, M. C., Lim, Y. L., Walton, A., Lefkovits, J., Agnelli, G., Goodman, S. G., Budaj, A., Gulba, D. C., Allegrone, J., Brieger, D., for the GRACE Investigators, (2007). Combining warfarin and antiplatelet therapy after coronary stenting in the Global Registry of Acute Coronary Events: is it safe and effective to use just one antiplatelet agent?. Eur Heart J 28: 1717-1722 [Abstract] [Full Text]  
• Meadows, T. A., Bhatt, D. L. (2007). Clinical Aspects of Platelet Inhibitors and Thrombus Formation. Circ. Res. 100: 1261-1275 [Abstract] [Full Text]  
• Howard-Alpe, G. M., de Bono, J., Hudsmith, L., Orr, W. P., Foex, P., Sear, J. W. (2007). Coronary artery stents and non-cardiac surgery. Br J Anaesth 98: 560-574 [Abstract] [Full Text]  
• Kikano, G. E., Brown, M. T. (2007). Antiplatelet Therapy for Atherothrombotic Disease: An Update for the Primary Care Physician. Mayo Clin Proc. 82: 583-593 [Abstract] [Full Text]  
• The Society of Thoracic Surgeons Blood Conservatio, , Ferraris, V. A., Ferraris, S. P., Saha, S. P., Hessel, E. A. II, Haan, C. K., Royston, B. D., Bridges, C. R., Higgins, R. S.D., Despotis, G., Brown, J. R., The Society of Cardiovascular Anesthesiologists Sp, , Spiess, B. D., Shore-Lesserson, L., Stafford-Smith, M., Mazer, C. D., Bennett-Guerrero, E., Hill, S. E., Body, S. (2007). Perioperative Blood Transfusion and Blood Conservation in Cardiac Surgery: The Society of Thoracic Surgeons and The Society of Cardiovascular Anesthesiologists Clinical Practice Guideline. Ann. Thorac. Surg. 83: S27-S86 [Abstract] [Full Text]  
• Angiolillo, D. J., Fernandez-Ortiz, A., Bernardo, E., Alfonso, F., Macaya, C., Bass, T. A., Costa, M. A. (2007). Variability in Individual Responsiveness to Clopidogrel: Clinical Implications, Management, and Future Perspectives. J Am Coll Cardiol 49: 1505-1516 [Abstract] [Full Text]  
• de Smet, B. J.G.L., Zijlstra, F. (2007). A look at drug eluting stents with optical coherence tomography. Eur Heart J 28: 918-919 [Full Text]  
• Tiroch, K., Koch, W., von Beckerath, N., Kastrati, A., Schomig, A. (2007). Heme oxygenase-1 gene promoter polymorphism and restenosis following coronary stenting. Eur Heart J 28: 968-973 [Abstract] [Full Text]  
• Ellis, S. G., Colombo, A., Grube, E., Popma, J., Koglin, J., Dawkins, K. D., Stone, G. W. (2007). Incidence, Timing, and Correlates of Stent Thrombosis With the Polymeric Paclitaxel Drug-Eluting Stent: A TAXUS II, IV, V, and VI Meta-Analysis of 3,445 Patients Followed for Up to 3 Years. J Am Coll Cardiol 49: 1043-1051 [Abstract] [Full Text]  
• Grines, C. L., Bonow, R. O., Casey, D. E. Jr, Gardner, T. J., Lockhart, P. B., Moliterno, D. J., O'Gara, P., Whitlow, P. (2007). Prevention of Premature Discontinuation of Dual Antiplatelet Therapy in Patients With Coronary Artery Stents: A Science Advisory From the American Heart Association, American College of Cardiology, Society for Cardiovascular Angiography and Interventions, American College of Surgeons, and American Dental Association, With Representation From the American College of Physicians. J Am Coll Cardiol 49: 734-739 [Abstract] [Full Text]  
• Grines, C. L., Bonow, R. O., Casey, D. E. Jr, Gardner, T. J., Lockhart, P. B., Moliterno, D. J., O'Gara, P., Whitlow, P. (2007). Prevention of Premature Discontinuation of Dual Antiplatelet Therapy in Patients With Coronary Artery Stents: A Science Advisory From the American Heart Association, American College of Cardiology, Society for Cardiovascular Angiography and Interventions, American College of Surgeons, and American Dental Association, With Representation From the American College of Physicians. Circulation 115: 813-818 [Abstract] [Full Text]  
• Clappers, N, Brouwer, M A, Verheugt, F W A (2007). Antiplatelet treatment for coronary heart disease. Heart 93: 258-265 [Full Text]  
• Dzau, V. J., Antman, E. M., Black, H. R., Hayes, D. L., Manson, J. E., Plutzky, J., Popma, J. J., Stevenson, W. (2006). The Cardiovascular Disease Continuum Validated: Clinical Evidence of Improved Patient Outcomes: Part I: Pathophysiology and Clinical Trial Evidence (Risk Factors Through Stable Coronary Artery Disease). Circulation 114: 2850-2870 [Full Text]  
• Joner, M., Finn, A. V., Farb, A., Mont, E. K., Kolodgie, F. D., Ladich, E., Kutys, R., Skorija, K., Gold, H. K., Virmani, R. (2006). Pathology of Drug-Eluting Stents in Humans: Delayed Healing and Late Thrombotic Risk. J Am Coll Cardiol 48: 193-202 [Abstract] [Full Text]  
• Ries, T., Buhk, J.-H., Kucinski, T., Goebell, E., Grzyska, U., Zeumer, H., Fiehler, J. (2006). Intravenous Administration of Acetylsalicylic Acid During Endovascular Treatment of Cerebral Aneurysms Reduces the Rate of Thromboembolic Events. Stroke 37: 1816-1821 [Abstract] [Full Text]  
• Stone, G. W., Aronow, H. D. (2006). Long-term Care After Percutaneous Coronary Intervention: Focus on the Role of Antiplatelet Therapy. Mayo Clin Proc. 81: 641-652 [Abstract] [Full Text]  
• Kapetanakis, E. I., Medlam, D. A., Petro, K. R., Haile, E., Hill, P. C., Dullum, M. K.C., Bafi, A. S., Boyce, S. W., Corso, P. J. (2006). Effect of Clopidogrel Premedication in Off-Pump Cardiac Surgery: Are We Forfeiting the Benefits of Reduced Hemorrhagic Sequelae?. Circulation 113: 1667-1674 [Abstract] [Full Text]  
• Franks, A. M, Gardner, S. F (2006). AGI-1067: A Novel Vascular Protectant for Prevention of Restenosis. The Annals of Pharmacotherapy 40: 66-73 [Abstract] [Full Text]  
• Sabatine, M. S., Cannon, C. P., Gibson, C. M., Lopez-Sendon, J. L., Montalescot, G., Theroux, P., Lewis, B. S., Murphy, S. A., McCabe, C. H., Braunwald, E., for the Clopidogrel as Adjunctive Reperfusion Ther, (2005). Effect of Clopidogrel Pretreatment Before Percutaneous Coronary Intervention in Patients With ST-Elevation Myocardial Infarction Treated With Fibrinolytics: The PCI-CLARITY Study. JAMA 294: 1224-1232 [Abstract] [Full Text]  
• Beinart, S. C., Kolm, P., Veledar, E., Zhang, Z., Mahoney, E. M., Bouin, O., Gabriel, S., Jackson, J., Chen, R., Caro, J., Steinhubl, S., Topol, E., Weintraub, W. S. (2005). Long-Term Cost Effectiveness of Early and Sustained Dual Oral Antiplatelet Therapy With Clopidogrel Given for Up to One Year After Percutaneous Coronary Intervention: Results From the Clopidogrel for the Reduction of Events During Observation (CREDO) Trial. J Am Coll Cardiol 46: 761-769 [Abstract] [Full Text]  
• De Luca, G., Suryapranata, H., Grimaldi, R., Chiariello, M. (2005). Coronary stenting and abciximab in primary angioplasty for ST-segment-elevation myocardial infarction. QJM 98: 633-641 [Abstract] [Full Text]  
• Rothberg, M. B., Celestin, C., Fiore, L. D., Lawler, E., Cook, J. R. (2005). Warfarin plus Aspirin after Myocardial Infarction or the Acute Coronary Syndrome: Meta-Analysis with Estimates of Risk and Benefit. ANN INTERN MED 143: 241-250 [Abstract] [Full Text]  
• Higashida, R. T., Halbach, V. V., Dowd, C. F., Juravsky, L., Meagher, S. (2005). Initial Clinical Experience with a New Self-Expanding Nitinol Stent for the Treatment of Intracranial Cerebral Aneurysms: The Cordis Enterprise Stent. Am. J. Neuroradiol. 26: 1751-1756 [Abstract] [Full Text]  
• Schomig, A., Schmitt, C., Dibra, A., Mehilli, J., Volmer, C., Schuhlen, H., Dirschinger, J., Dotzer, F., ten Berg, J. M., Neumann, F.-J., Berger, P. B., Kastrati, A., for the Intracoronary Stenting and Antithrombotic, (2005). One year outcomes with abciximab vs. placebo during percutaneous coronary intervention after pre-treatment with clopidogrel. Eur Heart J 26: 1379-1384 [Abstract] [Full Text]  
• Wiviott, S. D., Antman, E. M., Winters, K. J., Weerakkody, G., Murphy, S. A., Behounek, B. D., Carney, R. J., Lazzam, C., McKay, R. G., McCabe, C. H., Braunwald, E., for the JUMBO-TIMI 26 Investigators, (2005). Randomized Comparison of Prasugrel (CS-747, LY640315), a Novel Thienopyridine P2Y12 Antagonist, With Clopidogrel in Percutaneous Coronary Intervention: Results of the Joint Utilization of Medications to Block Platelets Optimally (JUMBO)-TIMI 26 Trial. Circulation 111: 3366-3373 [Abstract] [Full Text]  
• Wenaweser, P., Dorffler-Melly, J., Imboden, K., Windecker, S., Togni, M., Meier, B., Haeberli, A., Hess, O. M. (2005). Stent Thrombosis Is Associated With an Impaired Response to Antiplatelet Therapy. J Am Coll Cardiol 45: 1748-1752 [Abstract] [Full Text]  
• Wenaweser, P., Rey, C., Eberli, F. R., Togni, M., Tuller, D., Locher, S., Remondino, A., Seiler, C., Hess, O. M., Meier, B., Windecker, S. (2005). Stent thrombosis following bare-metal stent implantation: success of emergency percutaneous coronary intervention and predictors of adverse outcome. Eur Heart J 26: 1180-1187 [Abstract] [Full Text]  
• Iakovou, I., Schmidt, T., Bonizzoni, E., Ge, L., Sangiorgi, G. M., Stankovic, G., Airoldi, F., Chieffo, A., Montorfano, M., Carlino, M., Michev, I., Corvaja, N., Briguori, C., Gerckens, U., Grube, E., Colombo, A. (2005). Incidence, Predictors, and Outcome of Thrombosis After Successful Implantation of Drug-Eluting Stents. JAMA 293: 2126-2130 [Abstract] [Full Text]  
• Bath, P. M.W., Zhao, L., Heptinstall, S. (2005). Current status of stroke prevention in patients with atrial fibrillation. Eur Heart J Suppl 7: C12-C18 [Abstract] [Full Text]  
• Buresly, K., Eisenberg, M. J., Zhang, X., Pilote, L. (2005). Bleeding Complications Associated With Combinations of Aspirin, Thienopyridine Derivatives, and Warfarin in Elderly Patients Following Acute Myocardial Infarction. Arch Intern Med 165: 784-789 [Abstract] [Full Text]  
• Authors/Task Force Members, , Silber, S., Albertsson, P., Aviles, F. F., Camici, P. G., Colombo, A., Hamm, C., Jorgensen, E., Marco, J., Nordrehaug, J.-E., Ruzyllo, W., Urban, P., Stone, G. W., Wijns, W. (2005). Guidelines for Percutaneous Coronary Interventions: The Task Force for Percutaneous Coronary Interventions of the European Society of Cardiology. Eur Heart J 26: 804-847 [Full Text]  
• Ascione, R., Ghosh, A., Rogers, C. A., Cohen, A., Monk, C., Angelini, G. D. (2005). In-Hospital Patients Exposed to Clopidogrel Before Coronary Artery Bypass Graft Surgery: A Word of Caution. Ann. Thorac. Surg. 79: 1210-1216 [Abstract] [Full Text]  
• Claeys, M. J., Van der Planken, M. G., Bosmans, J. M., Michiels, J. J., Vertessen, F., Van Der Goten, P., Wuyts, F. L., Vrints, C. J. (2005). Does pre-treatment with aspirin and loading dose clopidogrel obviate the need for glycoprotein IIb/IIIa antagonists during elective coronary stenting? A focus on peri-procedural myonecrosis. Eur Heart J 26: 567-575 [Abstract] [Full Text]  
• Kapetanakis, E. I., Medlam, D. A., Boyce, S. W., Haile, E., Hill, P. C., Dullum, M. K.C., Bafi, A. S., Petro, K. R., Corso, P. J. (2005). Clopidogrel administration prior to coronary artery bypass grafting surgery: the cardiologist's panacea or the surgeon's headache?. Eur Heart J 26: 576-583 [Abstract] [Full Text]  
• Cowper, P. A., Udayakumar, K., Sketch, M. H. Jr, Peterson, E. D. (2005). Economic effects of prolonged clopidogrel therapy after percutaneous coronary intervention. J Am Coll Cardiol 45: 369-376 [Abstract] [Full Text]  
• Kandzari, D. E., Berger, P. B., Kastrati, A., Steinhubl, S. R., Mehilli, J., Dotzer, F., ten Berg, J. M., Neumann, F.-J., Bollwein, H., Dirschinger, J., Schomig, A., ISAR-REACT Study Investigators, (2004). Influence of treatment duration with a 600-mg dose of clopidogrel before percutaneous coronary revascularization. J Am Coll Cardiol 44: 2133-2136 [Abstract] [Full Text]  
• Koch, W., Mehilli, J., Pfeufer, A., Schomig, A., Kastrati, A. (2004). Apolipoprotein E gene polymorphisms and thrombosis and restenosis after coronary artery stenting. J. Lipid Res. 45: 2221-2226 [Abstract] [Full Text]  
• Lopez-Palop, R., Pinar, E., Lozano, I., Saura, D., Pico, F., Valdes, M. (2004). Utility of the fractional flow reserve in the evaluation of angiographically moderate in-stent restenosis. Eur Heart J 25: 2040-2047 [Abstract] [Full Text]  
• Reuthebuch, O., Kadner, A., Turina, M. I. (2004). Reply. Ann. Thorac. Surg. 78: 1878-1879 [Full Text]  
• Popma, J. J., Berger, P., Ohman, E. M., Harrington, R. A., Grines, C., Weitz, J. I. (2004). Antithrombotic Therapy During Percutaneous Coronary Intervention: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126: 576S-599S [Abstract] [Full Text]  
• van der Heijden, D. J., Westendorp, I. C. D., Riezebos, R. K., Kiemeneij, F., Slagboom, T., van der Wieken, L. R., Laarman, G.-J. (2004). Lack of efficacy of clopidogrel pre-treatment in the prevention of myocardial damage after elective stent implantation. J Am Coll Cardiol 44: 20-24 [Abstract] [Full Text]  
• Stadius, M. L. (2004). Diminishing returns ...and too many choices ...the saga of pharmacologic therapy to reduce the complications of percutaneous coronary intervention. J Am Coll Cardiol 44: 25-27 [Full Text]  
• Benza, R. L., Zoghbi, G. J., Tallaj, J., Brown, R., Kirklin, J. K., Hubbard, M., Rayburn, B., Foley, B., McGiffin, D. C., Pinderski, L. J., Misra, V., Bourge, R. C. (2004). Palliation of allograft vasculopathy with transluminal angioplasty: A decade of experience. J Am Coll Cardiol 43: 1973-1981 [Abstract] [Full Text]  
• Sim, D. S., Merrill-Skoloff, G., Furie, B. C., Furie, B., Flaumenhaft, R. (2004). Initial accumulation of platelets during arterial thrombus formation in vivo is inhibited by elevation of basal cAMP levels. Blood 103: 2127-2134 [Abstract] [Full Text]  
• Kastrati, A, Schomig, A, Schomig, E (2004). Are we making efficient use of clopidogrel?. Eur Heart J 25: 454-456 [Full Text]  
• Behan, M W H, Storey, R F (2004). Antiplatelet therapy in cardiovascular disease. Postgrad. Med. J. 80: 155-164 [Abstract] [Full Text]