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Previous Volume 334:1478-1479 May 30, 1996 Number 22 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The Case Records in the January 18 issue of the Journal¹ reflects the difficulties in distinguishing focal nodular hyperplasia from the fibrolamellar variant of hepatocellular carcinoma. Polysomies of chromosome 1, detected by conventional cytogenetic methods, may be characteristic of hepatocellular carcinoma.^2,3 We used fluorescence in situ hybridization, a simple and rapid method that allows the detection of chromosomal aberrations in interphase nuclei, to investigate the number of copies of chromosome 1 in cytologic preparations of malignant and benign liver tumors. Polysomy 1, mostly trisomy 1, was found only in hepatocellular carcinoma and not in normal liver tissue, . . . [Full Text of this Article]

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