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Correspondence
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Volume 334:1608-1609 June 13, 1996 Number 24
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Allelic Loss of Chromosome 1p in Neuroblastoma

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To the Editor: Many studies have shown amplification of the N-myc oncogene to be a highly reliable predictor of death from neuroblastoma.1,2,3 Caron et al. (Jan. 25 issue)3 report that allelic loss of chromosome 1p is a more powerful predictor of unfavorable outcome than N-myc amplification. Other studies of chromosome 1p loss, however, have been unable to assess its independent prognostic importance because it occurs so rarely in the absence of N-myc amplification.1,2 We suggest that a reanalysis of the data of Caron et al. might yield results similar to those in other large series.1,2

Caron et . . . [Full Text of this Article]

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