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Editorial
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Volume 334:1666-1667 June 20, 1996 Number 25
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Hereditary Angioedema

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"So soon as ever she came into the room I recognized the affection, for there lay, across the face from temple to temple, an oblong tumor almost closing both eyes." Thus, J.L. Milton in 1876 described one of his patients with angioedema, six years before Quincke introduced the term angioneurotic edema to describe this disease.1 As Dr. Milton pointed out, the clinical syndrome can be identified quickly, but its cause is not so easy to discern. Because of the severity of the symptoms and the need for a specific therapeutic approach, angioedema due to deficiency of C1 inhibitor must be . . . [Full Text of this Article]

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