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Previous Volume 334:1671-1673 June 20, 1996 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by O'Brien, W. A.

To the Editor: The interesting article by O'Brien et al. (Feb. 15 issue)¹ has several shortcomings. When measurements corresponding to the same time points are not available for all patients in a study, patients with samples obtained early after the start of antiretroviral therapy tend to have higher observed average reductions in human immunodeficiency virus (HIV) RNA than patients from whom samples were mostly obtained later; their actual responses may be different.

Second, since data on plasma levels of HIV RNA were missing for more than half the patients in the immediate-treatment group for any point beyond four months, the . . . [Full Text of this Article]

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