To the Editor: Mucosal candidiasis that is refractory to treatmentwith fluconazole is an increasingly common complication of humanimmunodeficiency virus (HIV) infection. In many cases, noneof the available oral antifungal agents are effective; in somecases, even intravenous amphotericin B provides only partialrelief. We describe a patient with fluconazole-resistant mucosalcandidiasis whose infection resolved after the initiation oftreatment with an antiretroviral agent combined with a proteaseinhibitor.
A 34-year-old man with HIV infection had CD4 counts of 4 to10 cells per cubic millimeter from November 1991 to January1996. He received didanosine from January 1992 . . . [Full Text of this Article]
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