FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 334:1743-1746 June 27, 1996 Number 26 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Hinchey, J. PubMed Citation

To the Editor: In their article "A Reversible Posterior Leukoencephalopathy Syndrome," Hinchey et al. (Feb. 22 issue)¹ described several cases of a condition that is clinically and radiographically similar to hypertensive encephalopathy^2,3 and the related syndrome of cyclosporine-induced neurotoxicity.⁴ These disorders have previously been well characterized.^2,3,4

Several points in the paper require clarification. Of greatest concern are the methodologic flaws in the study design that led the authors to conclude that the syndrome is always reversible. They retrospectively selected only patients with white-matter abnormalities who subsequently recovered from their neurologic event. This bias effectively excluded any patient with unusual findings . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Limaye, S., Cooper, J. (2009). The right scan at the right time: reversible posterior leukoencephalopathy syndrome mimicking bilateral occipital lobe infarcts. Age Ageing 38: 483-484 [Abstract] [Full Text]  
• Hinchey, J. A. (2008). Reversible Posterior Leukoencephalopathy Syndrome: What Have We Learned in the Last 10 Years?. Arch Neurol 65: 175-176 [Full Text]  
• Lee, V. H., Wijdicks, E. F. M., Manno, E. M., Rabinstein, A. A. (2008). Clinical Spectrum of Reversible Posterior Leukoencephalopathy Syndrome. Arch Neurol 65: 205-210 [Abstract] [Full Text]  
• Kapiteijn, E., Brand, A., Kroep, J., Gelderblom, H. (2007). Sunitinib induced hypertension, thrombotic microangiopathy and reversible posterior leukencephalopathy syndrome. Ann Oncol 18: 1745-1747 [Full Text]  
• Allen, J. A., Adlakha, A., Bergethon, P. R. (2006). Reversible Posterior Leukoencephalopathy Syndrome After Bevacizumab/FOLFIRI Regimen for Metastatic Colon Cancer.. Arch Neurol 63: 1475-1478 [Abstract] [Full Text]  
• Yong, P. F. K., Hamour, S. M. A., Burns, A. (2003). Reversible posterior leukoencephalopathy in a patient with systemic sclerosis/systemic lupus erythematosus overlap syndrome. Nephrol Dial Transplant 18: 2660-2662 [Full Text]  
• Garg, R K (2001). Posterior leukoencephalopathy syndrome. Postgrad. Med. J. 77: 24-24 [Abstract] [Full Text]  
• Casey, S. O., Sampaio, R. C., Michel, E., Truwit, C. L. (2000). Posterior Reversible Encephalopathy Syndrome: Utility of Fluid-attenuated Inversion Recovery MR Imaging in the Detection of Cortical and Subcortical Lesions. Am. J. Neuroradiol. 21: 1199-1206 [Abstract] [Full Text]  
• Burn, D J, Bates, D (1998). Neurology and the kidney. J. Neurol. Neurosurg. Psychiatry 65: 810-821 [Abstract] [Full Text]