At a conservative estimate, 50 million people worldwide haveepilepsy. The annual incidence ranges from 20 to 70 cases per100,0001 and the point prevalence is 0.4 to 0.8 percent.2 Theincidence rates are highest in childhood, plateau from the ageof 15 to 65 years, and rise again among the elderly. Overall,5 percent of persons report a seizure at some time in theirlives. This figure excludes febrile convulsions, which occurin approximately 5 percent of children. These data suggest thatthere is a substantial rate of remission, even among personswho never receive treatment with an antiepileptic . . . [Full Text of this Article]
Classification of Seizures and Epileptic Syndromes
Indications for Treatment
Choice of Drug
Carbamazepine
Phenytoin
Valproic Acid
Phenobarbital
Primidone
Ethosuximide
Clonazepam
Treatment of Refractory Epilepsy
Drug Monitoring
Drug Treatment during Pregnancy
Discontinuing Therapy
Referral to an Epilepsy Center
Conclusions
Source Information
From the Epilepsy Research Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland (M.J.B.), and the Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia (M.A.D.).
Address reprint requests to Dr. Brodie at the Epilepsy Research Unit, Department of Medicine and Therapeutics, Western Infirmary, Glasgow G11 6NT, Scotland.
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