Breast cancer is the most common cancer among women in the Westernworld, with a cumulative lifetime risk of 1 in 8.1 The two strongestrisk factors are age and a family history of breast cancer.Five years ago, a region on chromosome 17 was shown by linkageanalysis to have a substantial role in early-onset familialbreast and ovarian cancer.2 An intense gene-hunting effort ofthe "positional cloning" type3 culminated in the identificationof the BRCA1 gene in the fall of 1994.4,5 These results willrequire that all physicians who care for patients understandthe molecular genetics of breast . . . [Full Text of this Article]
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