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Previous Volume 334:269-270 January 25, 1996 Number 4 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: After the completion of the studies reported by DeFronzo et al. (Aug. 31 issue),¹ metformin was introduced into use in the United States. As of October 30, 1995, the Food and Drug Administration (FDA) Medwatch reporting program (1-800-FDA-1088) had received 10 reports of possible metformin-associated lactic acidosis. Of the three deaths attributed to lactic acidosis (Table 1), the diagnosis was substantiated in only two. Even in these two patients, factors other than metformin probably contributed to the development of lactic acidosis. Of the seven nonfatal cases of lactic acidosis attributed to metformin therapy, the diagnosis . . . [Full Text of this Article]

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