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Previous Volume 334:332-333 February 1, 1996 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The report by Knowles et al. (Sept. 28 issue)¹ and the accompanying editorial² on gene therapy for cystic fibrosis gave a very fair account of some of the difficulties involved. We are concerned, however, that the two articles taken together may send an unbalanced message. A study of liposome-based gene therapy reported recently,³ with a trial design very similar to that of Knowles et al., gave encouraging results — a correction of the chloride-permeability defect of approximately 20 percent without any adverse effects. Although this is unlikely to be adequate for therapy, the understanding of liposome-mediated gene . . . [Full Text of this Article]

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