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Figure 1. An eight-year-old girl was found to have proteinuria and microscopic hematuria on a routine examination. A photomicrograph (Panel A) shows an enlarged, lobulated glomerulus with irregular thickened glomerular capillary walls, often with a double-contour appearance, so-called tram tracks (arrowheads); moderate mesangial expansion; and moderate hypercellularity (periodic acidSchiff, x20). A fluorescence photomicrograph (Panel B) discloses coarse and bulky granular deposits of C3 along the glomerular capillary wall and, to a lesser extent, in mesangial areas (x25). A transmission electron micrograph (Panel C) reveals large, subendothelial, electron-dense deposits (asterisks) and mesangial interposition (x4000). CL . . . [Full Text of this Article] |