FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 334:529-530 February 22, 1996 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Osteolytic lesions are a hallmark of multiple myeloma. At the time of diagnosis, most patients have bone lesions whose extent is directly related to the mass of the tumor. About 30 percent of patients also have hypercalcemia. Bone lesions and hypercalcemia are major causes of morbidity in these patients, causing asthenia, cachexia, bone pain, fractures, compression of the spinal cord, and renal insufficiency. Thus, the diagnosis and treatment of bone disease are essential to the care of patients with multiple myeloma.

Unfortunately, the efficacy of treatment of the skeletal effects of multiple myeloma is very limited. Only patients who have . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Barille-Nion, S., Barlogie, B., Bataille, R., Bergsagel, P. L., Epstein, J., Fenton, R. G., Jacobson, J., Kuehl, W. M., Shaughnessy, J., Tricot, G. (2003). Advances in Biology and Therapy of Multiple Myeloma. ASH Education Book 2003: 248-278 [Abstract] [Full Text]  
• Teronen, O., Laitinen, M., Salo, T., Hanemaaijer, R., Heikkila, P., Konttinen, Y. T., Sorsa, T. (2000). Inhibition of matrix metalloproteinases by bisphosphonates may in part explain their effects in the treatment of multiple myeloma. Blood 96: 4006-4007 [Full Text]  
• Dallas, S. L., Garrett, I. R., Oyajobi, B. O., Dallas, M. R., Boyce, B. F., Bauss, F., Radl, J., Mundy, G. R. (1999). Ibandronate Reduces Osteolytic Lesions but not Tumor Burden in a Murine Model of Myeloma Bone Disease. Blood 93: 1697-1706 [Abstract] [Full Text]