To the Editor: The article by Walter et al. (Oct. 19 issue)1provides important evidence that the infusion of donorderivedCD8+ cytotoxic T-cell clones specific for human cytomegalovirusproteins can promptly reconstitute cellular immunity againsthuman cytomegalovirus in recipients of allogeneic bone marrow,thus reducing the risk of morbidity and mortality related toviral infection. However, we would like to comment on two points.
First, excretion of the virus in urine and its isolation fromthe throat have not been demonstrated to be predictive of cytomegalovirusdisease in humans,2 and consequently these measures should notbe used to monitor infection . . . [Full Text of this Article]
References
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