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Previous Volume 335:1224-1226 October 17, 1996 Number 16 Next

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Apoptosis (or programmed cell death) is a central feature of normal tissue development in the fetus and of cell replacement in certain adult tissues (e.g., the thymus).¹ In contrast to necrosis (or accidental cell death), apoptosis is a tightly regulated series of energy-dependent molecular and biochemical events orchestrated by a genetic program. Cells undergoing apoptosis can be distinguished from those undergoing necrosis by several characteristic features, including blebbing of the cell membrane, a reduction in cell volume, and condensation of nuclear chromatin. In contrast to necrosis, apoptosis usually occurs in isolated cells without inflammation.

For a single cell, the process . . . [Full Text of this Article]

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• Quenot, J.-P., Le Teuff, G., Quantin, C., Doise, J.-M., Abrahamowicz, M., Masson, D., Blettery, B. (2005). Myocardial Injury in Critically Ill Patients: Relation to Increased Cardiac Troponin I and Hospital Mortality. Chest 128: 2758-2764 [Abstract] [Full Text]  
• Hotchkiss, R. S., Osmon, S. B., Chang, K. C., Wagner, T. H., Coopersmith, C. M., Karl, I. E. (2005). Accelerated Lymphocyte Death in Sepsis Occurs by both the Death Receptor and Mitochondrial Pathways. J. Immunol. 174: 5110-5118 [Abstract] [Full Text]  
• Pang, J.-J., Xu, R.-K., Xu, X.-B., Cao, J.-M., Ni, C., Zhu, W.-L., Asotra, K., Chen, M.-C., Chen, C. (2004). Hexarelin protects rat cardiomyocytes from angiotensin II-induced apoptosis in vitro. Am. J. Physiol. Heart Circ. Physiol. 286: H1063-H1069 [Abstract] [Full Text]  
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• van der Laarse, A. (2002). Hypothesis: troponin degradation is one of the factors responsible for deterioration of left ventricular function in heart failure. Cardiovasc Res 56: 8-14 [Abstract] [Full Text]  
• Agusti, A. G. N., Sauleda, J., Miralles, C., Gomez, C., Togores, B., Sala, E., Batle, S., Busquets, X. (2002). Skeletal Muscle Apoptosis and Weight Loss in Chronic Obstructive Pulmonary Disease. Am. J. Respir. Crit. Care Med. 166: 485-489 [Abstract] [Full Text]  
• Kay, D. G., Yue, P., Hanna, Z., Jothy, S., Tremblay, E., Jolicoeur, P. (2002). Cardiac Disease in Transgenic Mice Expressing Human Immunodeficiency Virus-1 Nef in Cells of the Immune System. Am. J. Pathol. 161: 321-335 [Abstract] [Full Text]  
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• Cook, S.A., Poole-Wilson, P.A. (1999). Cardiac myocyte apoptosis. Eur Heart J 20: 1619-1629  
• Wollert, K. C, Drexler, H. (1999). The renin-angiotensin system and experimental heart failure. Cardiovasc Res 43: 838-849 [Abstract] [Full Text]  
• Dispersyn, G. D., Ausma, J., Thone, F., Flameng, W., Vanoverschelde, J.-L. J., Allessie, M. A., Ramaekers, F. C.S., Borgers, M. (1999). Cardiomyocyte remodelling during myocardial hibernation and atrial fibrillation: prelude to apoptosis. Cardiovasc Res 43: 947-957 [Abstract] [Full Text]  
• Mann, D. L. (1999). Mechanisms and Models in Heart Failure : A Combinatorial Approach. Circulation 100: 999-1008 [Full Text]  
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• Lo, B., Snyder, L., Sox, H. C. (1999). Care at the End of Life: Guiding Practice Where There Are No Easy Answers. ANN INTERN MED 130: 772-774 [Full Text]  
• Adams, V., Jiang, H., Yu, J., Mobius-Winkler, S., Fiehn, E., Linke, A., Weigl, C., Schuler, G., Hambrecht, R. (1999). Apoptosis in skeletal myocytes of patients with chronic heart failure is associated with exercise intolerance. J Am Coll Cardiol 33: 959-965 [Abstract] [Full Text]  
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• Gotsman, M. S., Admon, D. (1998). Paradigm Shifts in Coronary Artery Disease: The Old New Initiatives. Arch Intern Med 158: 949-953 [Full Text]  
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• Hetts, S. W. (1998). To Die or Not to Die: An Overview of Apoptosis and Its Role in Disease. JAMA 279: 300-307 [Abstract] [Full Text]  
• Gheorghiade, M., Bonow, R. O. (1998). Chronic Heart Failure in the United States : A Manifestation of Coronary Artery Disease. Circulation 97: 282-289 [Full Text]  
• Leri, A., Liu, Y., Malhotra, A., Li, Q., Stiegler, P., Claudio, P. P., Giordano, A., Kajstura, J., Hintze, T. H., Anversa, P. (1998). Pacing-Induced Heart Failure in Dogs Enhances the Expression of p53 and p53-Dependent Genes in Ventricular Myocytes. Circulation 97: 194-203 [Abstract] [Full Text]  
• Jones, B. A., Gores, G. J. (1997). Physiology and pathophysiology of apoptosis in epithelial cells of the liver, pancreas, and intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 273: G1174-G1188 [Abstract] [Full Text]  
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• Diez, J., Panizo, A., Hernandez, M., Vega, F., Sola, I., Fortuno, M. A., Pardo, J. (1997). Cardiomyocyte Apoptosis and Cardiac Angiotensin-Converting Enzyme in Spontaneously Hypertensive Rats. Hypertension 30: 1029-1034 [Abstract] [Full Text]  
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