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Correspondence
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Volume 335:1235-1237 October 17, 1996 Number 16
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Pitfalls of Genetic Testing

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 by Charache, S.
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 by Hubbard, R.
To the Editor: In their discussion of pitfalls of genetic testing (May 2 issue)1 Hubbard and Lewontin seriously misrepresent several issues with regard to predictive genetic testing for mutations in the BRCA1 gene, and specifically testing for the 185delAG mutation in Jews. Their view that "DNA tests cannot usually help clinicians or benefit patients" is inconsistent with the view of many experts in medical genetics. In the same issue of the Journal, Haber et al. state that the 185delAG mutation is likely to be "a fully penetrant allele" and that the lifetime risk of breast cancer in 185delAG carriers is . . . [Full Text of this Article]

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