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Previous Volume 335:1242-1243 October 17, 1996 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In their Brief Report (April 25 issue),¹ Kreuder et al. report the aggravation of rhabdomyolysis by fever and suggest thermolability of the mutant enzyme as a possible cause for the increase. An additional or alternative explanation is that conditions of metabolic stress that produce fever also alter the energy metabolism profoundly, in particular by causing a dramatic acceleration of anaerobic glycolysis^2,3 that occurs largely in skeletal muscle. The elevation of body temperature also increases oxygen consumption and concomitantly increases the energy requirements of the whole body. Interleukin-1 and tumor necrosis factor are the two proximate cytokines that . . . [Full Text of this Article]

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