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Previous Volume 335:1369-1377 October 31, 1996 Number 18 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Most immune responses depend on the activation of T cells. This class of lymphocytes consists of functionally and phenotypically distinct populations, the best characterized of which are helper T cells and cytotoxic T cells. Distinctive molecules on the cell surface provide markers of these populations: CD4 for helper T cells and CD8 for cytotoxic T cells. CD4 and CD8 T cells recognize antigens through a T-cell antigen receptor composed of an chain and a chain. Other T cells bearing - and -chain receptors have been identified, but their function is less clear.

CD4 helper T cells can be divided into . . . [Full Text of this Article]

The Features of T-Cell Costimulation

The Clinical Relevance of T-Cell Costimulation

The Immunobiology of the B7:CD28/CTLA-4 Costimulatory Pathway

CD28 and CTLA-4

The Regulation of B7-1 and B7-2 Expression

The Role of B7-1 and B7-2 Molecules

The B7 Costimulatory Pathway and Disease

B7 Molecules in Infectious Disease

The B7:CD28/CTLA-4 Pathway in Autoimmunity

Conclusions

Source Information

From the Department of Pathology, Harvard Medical School, and the Division of Lymphocyte Biology, Dana–Farber Cancer Institute (H.R.); and the Department of Pathology, Tufts University School of Medicine, and the New England Medical Center (M.J.S.) — all in Boston.

Address reprint requests to Dr. Stadecker at the Department of Pathology, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111.

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