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Correspondence
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Volume 335:1397 October 31, 1996 Number 18
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Ganciclovir-Induced Psychosis

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To the Editor: Several reports of ganciclovir-induced psychiatric disturbances have been reported in the medical literature.1,2,3 Two cases involved patients with mild renal insufficiency1,2 and one a patient who was undergoing hemodialysis.3 Since ganciclovir is primarily eliminated through the kidney as the parent compound (91 percent),4 renal failure probably contributed to these cases. We describe a case of ganciclovir-induced psychosis that was not associated with renal insufficiency.

A 43-year-old man with advanced human immunodeficiency virus disease (CD4 lymphocyte count, 17 per cubic millimeter in October 1995) was admitted because of acute changes in mental status. He was incontinent and disoriented . . . [Full Text of this Article]

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