To the Editor: Several reports of ganciclovir-induced psychiatricdisturbances have been reported in the medical literature.1,2,3Two cases involved patients with mild renal insufficiency1,2and one a patient who was undergoing hemodialysis.3 Since gancicloviris primarily eliminated through the kidney as the parent compound(91 percent),4 renal failure probably contributed to these cases.We describe a case of ganciclovir-induced psychosis that wasnot associated with renal insufficiency.
A 43-year-old man with advanced human immunodeficiency virusdisease (CD4 lymphocyte count, 17 per cubic millimeter in October1995) was admitted because of acute changes in mental status.He was incontinent and disoriented . . . [Full Text of this Article]
References
This article has been cited by other articles:
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(1997). More on Ganciclovir-Induced "Psychosis". NEJM
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