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Previous Volume 335:1445-1453 November 7, 1996 Number 19 Next

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Since their discovery, antimicrobial drugs have proved remarkably effective for the control of bacterial infections. However, it was soon evident that bacterial pathogens were unlikely to surrender unconditionally, because some pathogens rapidly became resistant to many of the first effective drugs. For example, the development of resistance to penicillin in Staphylococcus aureus by the production of a -lactamase quickly decreased the usefulness of penicillin for serious staphylococcal infections, especially among hospitalized patients, in whom resistant strains are frequently found before they spread to the community.¹ Initially, the problem of bacterial resistance to antimicrobial drugs was solved by the discovery of . . . [Full Text of this Article]

Extended-Spectrum -Lactamases as a Cause of Antimicrobial-Drug Resistance

Penicillin-Resistant Pneumococci

Vancomycin Resistance in Enterococci

Conclusions

Source Information

From the Division of Infectious Diseases (H.S.G.) and the Department of Medicine (H.S.G., R.C.M.), Deaconess Hospital and Harvard Medical School, Boston.

Address reprint requests to Dr. Moellering at the Department of Medicine, Deaconess Hospital, 1 Deaconess Rd., Boston, MA 02215.

References

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• Singh, S. K., Gupta, K., Tiwari, S., Shahi, S. K., Kumar, S., Kumar, A., Gupta, S. K. (2009). Detecting Aerobic Bacterial Diversity in Patients With Diabetic Foot Wounds Using ERIC-PCR: A Preliminary Communication. INT J LOW EXTREM WOUNDS 8: 203-208 [Abstract]  
• Mourino, V., Boccaccini, A. R. (2009). Bone tissue engineering therapeutics: controlled drug delivery in three-dimensional scaffolds. J R Soc Interface 0: rsif.2009.0379v1-rsif20090379 [Abstract] [Full Text]  
• Kurokawa, K., Hamamoto, H., Matsuo, M., Nishida, S., Yamane, N., Lee, B. L., Murakami, K., Maki, H., Sekimizu, K. (2009). Evaluation of Target Specificity of Antibacterial Agents Using Staphylococcus aureus ddlA Mutants and D-Cycloserine in a Silkworm Infection Model. Antimicrob. Agents Chemother. 53: 4025-4027 [Abstract] [Full Text]  
• Hamburger, J. B., Hoertz, A. J., Lee, A., Senturia, R. J., McCafferty, D. G., Loll, P. J. (2009). A crystal structure of a dimer of the antibiotic ramoplanin illustrates membrane positioning and a potential Lipid II docking interface. Proc. Natl. Acad. Sci. USA 106: 13759-13764 [Abstract] [Full Text]  
• Eiland, E. H. III, Gatlin, D. (2008). Forecast of Antibiotic Development in an Era of Increasing Bacterial Resistance. Journal of Pharmacy Practice 21: 313-318 [Abstract]  
• Grabsch, E. A., Chua, K., Xie, S., Byrne, J., Ballard, S. A., Ward, P. B., Grayson, M. L. (2008). Improved Detection of vanB2-Containing Enterococcus faecium with Vancomycin Susceptibility by Etest Using Oxgall Supplementation. J. Clin. Microbiol. 46: 1961-1964 [Abstract] [Full Text]  
• Rodloff, A. C., Goldstein, E. J. C., Torres, A. (2006). Two decades of imipenem therapy. J Antimicrob Chemother 58: 916-929 [Abstract] [Full Text]  
• Scheetz, M. H., Hurt, K. M., Noskin, G. A., Oliphant, C. M. (2006). Applying antimicrobial pharmacodynamics to resistant gram-negative pathogens.. Am J Health Syst Pharm 63: 1346-1360 [Abstract] [Full Text]  
• Marchetti, F., Ronfani, L., Nibali, S. C., Tamburlini, G., for the Italian Study Group on Acute Otitis Media, (2005). Delayed Prescription May Reduce the Use of Antibiotics for Acute Otitis Media: A Prospective Observational Study in Primary Care. Arch Pediatr Adolesc Med 159: 679-684 [Abstract] [Full Text]  
• Bratu, S., Landman, D., Haag, R., Recco, R., Eramo, A., Alam, M., Quale, J. (2005). Rapid Spread of Carbapenem-Resistant Klebsiella pneumoniae in New York City: A New Threat to Our Antibiotic Armamentarium. Arch Intern Med 165: 1430-1435 [Abstract] [Full Text]  
• Cizman, M., Srovin, T., Pokorn, M., Cad Pecar, S., Battelino, S. (2005). Analysis of the causes and consequences of decreased antibiotic consumption over the last 5 years in Slovenia. J Antimicrob Chemother 55: 758-763 [Abstract] [Full Text]  
• Patel, G. P., Crank, C. W. (2005). Gram-Negative Resistance in the Intensive Care Unit. Journal of Pharmacy Practice 18: 91-99 [Abstract]  
• Jha, A. K., Bais, H. P., Vivanco, J. M. (2005). Enterococcus faecalis Mammalian Virulence-Related Factors Exhibit Potent Pathogenicity in the Arabidopsis thaliana Plant Model. Infect. Immun. 73: 464-475 [Abstract] [Full Text]  
• Tsai, J.-C., Hsueh, P.-R., Lin, H.-M., Chang, H.-J., Ho, S.-W., Teng, L.-J. (2005). Identification of Clinically Relevant Enterococcus Species by Direct Sequencing of groES and Spacer Region. J. Clin. Microbiol. 43: 235-241 [Abstract] [Full Text]  
• Epstein, B. J, Gums, J. G, Drlica, K. (2004). The Changing Face of Antibiotic Prescribing: The Mutant Selection Window. The Annals of Pharmacotherapy 38: 1675-1682 [Abstract] [Full Text]  
• Spiro, D. M., King, W. D., Arnold, D. H., Johnston, C., Baldwin, S. (2004). A Randomized Clinical Trial to Assess the Effects of Tympanometry on the Diagnosis and Treatment of Acute Otitis Media. Pediatrics 114: 177-181 [Abstract] [Full Text]  
• Bethea, J A., Walko, C. M, Targos, P. A (2004). Treatment of Vancomycin-Resistant Enterococcus with Quinupristin/Dalfopristin and High-Dose Ampicillin. The Annals of Pharmacotherapy 38: 989-991 [Abstract] [Full Text]  
• Emmert, E. A. B., Klimowicz, A. K., Thomas, M. G., Handelsman, J. (2004). Genetics of Zwittermicin A Production by Bacillus cereus. Appl. Environ. Microbiol. 70: 104-113 [Abstract] [Full Text]  
• Clark, J. P., Langston, E. (2003). Ketolides: A New Class of Antibacterial Agents for Treatment of Community-Acquired Respiratory Tract Infections in a Primary Care Setting. Mayo Clin Proc. 78: 1113-1124 [Abstract]  
• Safdar, N., Narans, L., Gordon, B., Maki, D. G. (2003). Comparison of Culture Screening Methods for Detection of Nasal Carriage of Methicillin-Resistant Staphylococcus aureus: a Prospective Study Comparing 32 Methods. J. Clin. Microbiol. 41: 3163-3166 [Abstract] [Full Text]  
• Smith, P. F., Birmingham, M. C., Noskin, G. A., Meagher, A. K., Forrest, A., Rayner, C. R., Schentag, J. J. (2003). Safety, efficacy and pharmacokinetics of linezolid for treatment of resistant Gram-positive infections in cancer patients with neutropenia. Ann Oncol 14: 795-801 [Abstract] [Full Text]  
• Moellering, R. C. Jr. (2003). Linezolid: The First Oxazolidinone Antimicrobial. ANN INTERN MED 138: 135-142 [Abstract] [Full Text]  
• Safdar, A., Armstrong, D. (2003). Antimicrobial Activities against 84 Listeria monocytogenes Isolates from Patients with Systemic Listeriosis at a Comprehensive Cancer Center (1955-1997). J. Clin. Microbiol. 41: 483-485 [Abstract] [Full Text]  
• Bickels, J., Ben-Sira, L., Kessler, A., Wientroub, S. (2002). Primary Pyomyositis. JBJS 84: 2277-2286 [Full Text]  
• Conly, J. (2002). Antimicrobial resistance in Canada. CMAJ 167: 885-891 [Abstract] [Full Text]  
• Safdar, N., Maki, D. G. (2002). The Commonality of Risk Factors for Nosocomial Colonization and Infection with Antimicrobial-Resistant Staphylococcus aureus, Enterococcus, Gram-Negative Bacilli, Clostridium difficile, and Candida. ANN INTERN MED 136: 834-844 [Abstract] [Full Text]  
• Kustanovich, I., Shalev, D. E., Mikhlin, M., Gaidukov, L., Mor, A. (2002). Structural Requirements for Potent Versus Selective Cytotoxicity for Antimicrobial Dermaseptin S4 Derivatives. J. Biol. Chem. 277: 16941-16951 [Abstract] [Full Text]  
• Jean, S.-S., Teng, L.-J., Hsueh, P.-R., Ho, S.-W., Luh, K.-T. (2002). Antimicrobial susceptibilities among clinical isolates of extended-spectrum cephalosporin-resistant Gram-negative bacteria in a Taiwanese University Hospital. J Antimicrob Chemother 49: 69-76 [Abstract] [Full Text]  
• Osmon, D. R. (2001). Antimicrobial Resistance: Guidelines for the Practicing Orthopaedic Surgeon. JBJS 83: 1891-1901 [Full Text]  
• Niederman, M. S., Mandell, L. A., Anzueto, A., Bass, J. B., Broughton, W. A., Campbell, G. D., Dean, N., File, T., Fine, M. J., Gross, P. A., Martinez, F., Marrie, T. J., Plouffe, J. F., Ramirez, J., Sarosi, G. A., Torres, A., Wilson, R., Yu, V. L. (2001). Guidelines for the Management of Adults with Community-acquired Pneumonia . Diagnosis, Assessment of Severity, Antimicrobial Therapy, and Prevention. Am. J. Respir. Crit. Care Med. 163: 1730-1754 [Full Text]  
• Sewnath, M. E., Olszyna, D. P., Birjmohun, R., ten Kate, F. J. W., Gouma, D. J., van der Poll, T. (2001). IL-10-Deficient Mice Demonstrate Multiple Organ Failure and Increased Mortality During Escherichia coli Peritonitis Despite an Accelerated Bacterial Clearance. J. Immunol. 166: 6323-6331 [Abstract] [Full Text]  
• Pavia, C. S., Wormser, G. P., Nowakowski, J., Cacciapuoti, A. (2001). Efficacy of an Evernimicin (SCH27899) In Vitro and in an Animal Model of Lyme Disease. Antimicrob. Agents Chemother. 45: 936-937 [Abstract] [Full Text]  
• Kollef, M. H., Fraser, V. J. (2001). Antibiotic Resistance in the Intensive Care Unit. ANN INTERN MED 134: 298-314 [Abstract] [Full Text]  
• Fung, H. B., Kuczynski, S., Finch, D. A., Ramos, L. (2001). Current Issues in Gram-Negative Resistance: Extended-Spectrum Beta-Lactamases and Inducible Beta-Lactamases. Journal of Pharmacy Practice 14: 6-17 [Abstract]  
• Lynch, J. P. III (2001). Hospital-Acquired Pneumonia : Risk Factors, Microbiology, and Treatment. Chest 119 : 373S-384S [Abstract] [Full Text]  
• Fiel, S. (2001). Guidelines and Critical Pathways for Severe Hospital-Acquired Pneumonia. Chest 119 : 412S-418S [Abstract] [Full Text]  
• Boucher, H. W., Thauvin-Eliopoulos, C., Loebenberg, D., Eliopoulos, G. M. (2001). In Vivo Activity of Evernimicin (SCH 27899) against Methicillin-Resistant Staphylococcus aureus in Experimental Infective Endocarditis. Antimicrob. Agents Chemother. 45: 208-211 [Abstract] [Full Text]  
• Tenover, F. C., Mohammed, M. J., Stelling, J., O'Brien, T., Williams, R. (2001). Ability of Laboratories To Detect Emerging Antimicrobial Resistance: Proficiency Testing and Quality Control Results from the World Health Organization's External Quality Assurance System for Antimicrobial Susceptibility Testing. J. Clin. Microbiol. 39: 241-250 [Abstract] [Full Text]  
• Warren, J. R., Farmer, J. J. III, Dewhirst, F. E., Birkhead, K., Zembower, T., Peterson, L. R., Sims, L., Bhattacharya, M. (2000). Outbreak of Nosocomial Infections Due to Extended-Spectrum beta -Lactamase-Producing Strains of Enteric Group 137, a New Member of the Family Enterobacteriaceae Closely Related to Citrobacter farmeri and Citrobacter amalonaticus. J. Clin. Microbiol. 38: 3946-3952 [Abstract] [Full Text]  
• KARAM, G. H., HEFFNER, J. E. (2000). Emerging Issues in Antibiotic Resistance in Blood-borne Infections. Am. J. Respir. Crit. Care Med. 162: 1610-1616 [Full Text]  
• Cetinkaya, Y., Falk, P., Mayhall, C. G. (2000). Vancomycin-Resistant Enterococci. Clin. Microbiol. Rev. 13: 686-707 [Abstract] [Full Text]  
• Boucher, H. W., Wennersten, C. B., Eliopoulos, G. M. (2000). In Vitro Activities of the Glycylcycline GAR-936 against Gram-Positive Bacteria. Antimicrob. Agents Chemother. 44: 2225-2229 [Abstract] [Full Text]  
• Bradley, J. S., Kearns, G. L., Reed, M. D., Capparelli, E. V., Vincent, J., The Pediatric Pharmacology Research Unit Network, (2000). Pharmacokinetics of a Fluoronaphthyridone, Trovafloxacin (CP 99,219), in Infants and Children following Administration of a Single Intravenous Dose of Alatrofloxacin. Antimicrob. Agents Chemother. 44: 1195-1199 [Abstract] [Full Text]  
• Rosamond, J., Allsop, A. (2000). Harnessing the Power of the Genome in the Search for New Antibiotics. Science 287: 1973-1976 [Abstract] [Full Text]  
• Waterer, G. W., Jennings, S. G., Wunderink, R. G. (1999). The Impact of Blood Cultures on Antibiotic Therapy in Pneumococcal Pneumonia. Chest 116: 1278-1281 [Abstract] [Full Text]  
• Mazmanian, S. K., Liu, G., Ton-That, H., Schneewind, O. (1999). Staphylococcus aureus Sortase, an Enzyme that Anchors Surface Proteins to the Cell Wall. Science 285: 760-763 [Abstract] [Full Text]  
• Nathwani, D., Davey, P. (1999). Antibiotic prescribing—are there lessons for physicians?. QJM 92: 287-292 [Full Text]  
• Gonzales, R., Steiner, J. F., Lum, A., Barrett, P. H. Jr (1999). Decreasing Antibiotic Use in Ambulatory Practice: Impact of a Multidimensional Intervention on the Treatment of Uncomplicated Acute Bronchitis in Adults. JAMA 281: 1512-1519 [Abstract] [Full Text]  
• Shepard, B. D., Gilmore, M. S. (1999). Identification of Aerobically and Anaerobically Induced Genes in Enterococcus faecalis by Random Arbitrarily Primed PCR. Appl. Environ. Microbiol. 65: 1470-1476 [Abstract] [Full Text]  
• Moir, D. T., Shaw, K. J., Hare, R. S., Vovis, G. F. (1999). Genomics and Antimicrobial Drug Discovery. Antimicrob. Agents Chemother. 43: 439-446 [Full Text]  
• File, T. M. Jr. (1999). Overview of Resistance in the 1990s. Chest 115 : 3S-8S [Abstract] [Full Text]  
• Wiener, J., Quinn, J. P., Bradford, P. A., Goering, R. V., Nathan, C., Bush, K., Weinstein, R. A. (1999). Multiple Antibiotic-Resistant Klebsiella and Escherichia coli in Nursing Homes. JAMA 281: 517-523 [Abstract] [Full Text]  
• Kollef, M. H., Sherman, G., Ward, S., Fraser, V. J. (1999). Inadequate Antimicrobial Treatment of Infections: A Risk Factor for Hospital Mortality Among Critically Ill Patients. Chest 115: 462-474 [Abstract] [Full Text]  
• Damoiseaux, R. A., de Melker, R. A, Ausems, M. J., van Balen, F. A. (1999). Reasons for non-guideline-based antibiotic prescriptions for acute otitis media in The Netherlands. Fam Pract 16: 50-53 [Abstract] [Full Text]  
• Rosen, H., Hajdu, R., Silver, L., Kropp, H., Dorso, K., Kohler, J., Sundelof, J. G., Huber, J., Hammond, G. G., Jackson, J. J., Gill, C. J., Thompson, R., Pelak, B. A., Epstein-Toney, J. H., Lankas, G., Wilkening, R. R., Wildonger, K. J., Blizzard, T. A., DiNinno, F. P., Ratcliffe, R. W., Heck, J. V., Kozarich, J. W., Hammond, M. L. (1999). Reduced Immunotoxicity and Preservation of Antibacterial Activity in a Releasable Side-Chain Carbapenem Antibiotic. Science 283: 703-706 [Abstract] [Full Text]  
• Wheeler, A. P., Bernard, G. R. (1999). Treating Patients with Severe Sepsis. NEJM 340: 207-214 [Full Text]  
• Moellering, R. C. Jr. (1999). A Novel Antimicrobial Agent Joins the Battle against Resistant Bacteria. ANN INTERN MED 130: 155-157 [Full Text]  
• Woodnutt, G., Berry, V. (1999). Two Pharmacodynamic Models for Assessing the Efficacy of Amoxicillin-Clavulanate against Experimental Respiratory Tract Infections Caused by Strains of Streptococcus pneumoniae. Antimicrob. Agents Chemother. 43: 29-34 [Abstract] [Full Text]  
• Woodnutt, G., Berry, V. (1999). Efficacy of High-Dose Amoxicillin-Clavulanate against Experimental Respiratory Tract Infections Caused by Strains of Streptococcus pneumoniae. Antimicrob. Agents Chemother. 43: 35-40 [Abstract] [Full Text]  
• Soltys, J., Quinn, M. T. (1999). Modulation of Endotoxin- and Enterotoxin-Induced Cytokine Release by In Vivo Treatment with beta -(1,6)-Branched beta -(1,3)-Glucan. Infect. Immun. 67: 244-252 [Abstract] [Full Text]  
• Anthonisen, N. R. (1999). Steroids in COPD : The Nearly Eternal Question. Chest 115: 3-4 [Full Text]  
• Rahal, J. J., Urban, C., Horn, D., Freeman, K., Segal-Maurer, S., Maurer, J., Mariano, N., Marks, S., Burns, J. M., Dominick, D., Lim, M. (1998). Class Restriction of Cephalosporin Use to Control Total Cephalosporin Resistance in Nosocomial Klebsiella. JAMA 280: 1233-1237 [Abstract] [Full Text]  
• Struelens, M. J (1998). The epidemiology of antimicrobial resistance in hospital acquired infections: problems and possible solutions. BMJ 317: 652-654 [Full Text]  
• Gill, C. J., Jackson, J. J., Gerckens, L. S., Pelak, B. A., Thompson, R. K., Sundelof, J. G., Kropp, H., Rosen, H. (1998). In Vivo Activity and Pharmacokinetic Evaluation of a Novel Long-Acting Carbapenem Antibiotic, MK-826 (L-749,345). Antimicrob. Agents Chemother. 42: 1996-2001 [Abstract] [Full Text]  
• Bergeron, M. G., Ouellette, M. (1998). Preventing Antibiotic Resistance through Rapid Genotypic Identification of Bacteria and of Their Antibiotic Resistance Genes in the Clinical Microbiology Laboratory. J. Clin. Microbiol. 36: 2169-2172 [Full Text]  
• Colsky, A. S., Kirsner, R. S., Kerdel, F. A. (1998). Analysis of Antibiotic Susceptibilities of Skin Wound Flora in Hospitalized Dermatology Patients: The Crisis of Antibiotic Resistance Has Come to the Surface. Arch Dermatol 134: 1006-1009 [Abstract] [Full Text]  
• Thomas, J. K., Forrest, A., Bhavnani, S. M., Hyatt, J. M., Cheng, A., Ballow, C. H., Schentag, J. J. (1998). Pharmacodynamic Evaluation of Factors Associated with the Development of Bacterial Resistance in Acutely Ill Patients during Therapy. Antimicrob. Agents Chemother. 42: 521-527 [Abstract] [Full Text]  
• Kernodle, D. S., Gates, H., Kaiser, A. B. (1998). Prophylactic Anti-Infective Activity of Poly-[1-6]-beta -D-Glucopyranosyl-[1-3]-beta -D-Glucopyranose Glucan in a Guinea Pig Model of Staphylococcal Wound Infection. Antimicrob. Agents Chemother. 42: 545-549 [Abstract] [Full Text]  
• Wang, Y., Russo, T. A., Kwon, O., Chanock, S., Rumsey, S. C., Levine, M. (1997). Ascorbate recycling in human neutrophils: Induction by bacteria. Proc. Natl. Acad. Sci. USA 94: 13816-13819 [Abstract] [Full Text]  
• Culpepper, L., Froom, J. (1997). Routine Antimicrobial Treatment of Acute Otitis Media: Is it Necessary?. JAMA 278: 1643-1645 [Abstract]  
• Daigle, D. M., McKay, G. A., Wright, G. D. (1997). Inhibition of Aminoglycoside Antibiotic Resistance Enzymes by Protein Kinase Inhibitors. J. Biol. Chem. 272: 24755-24758 [Abstract] [Full Text]  
• Niederman, M. S. (1997). Is "Crop Rotation" of Antibiotics the Solution to a "Resistant" Problem in the ICU?. Am. J. Respir. Crit. Care Med. 156: 1029-1031 [Full Text]  
• Park, I.-S., Lin, C.-H., Walsh, C. T. (1997). Bacterial resistance to vancomycin: Overproduction, purification, and characterization of VanC2 from Enterococcus casseliflavus as a D-Ala-D-Ser ligase. Proc. Natl. Acad. Sci. USA 94: 10040-10044 [Abstract] [Full Text]  
• Seppala, H., Klaukka, T., Vuopio-Varkila, J., Muotiala, A., Helenius, H., Lager, K., Huovinen, P., The Finnish Study Group for Antimicrobial Resistan, (1997). The Effect of Changes in the Consumption of Macrolide Antibiotics on Erythromycin Resistance in Group A Streptococci in Finland. NEJM 337: 441-446 [Abstract] [Full Text]  
• Mazmanian, S. K., Liu, G., Jensen, E. R., Lenoy, E., Schneewind, O. (2000). From the Cover: Staphylococcus aureus sortase mutants defective in the display of surface proteins and in the pathogenesis of animal infections. Proc. Natl. Acad. Sci. USA 97: 5510-5515 [Abstract] [Full Text]