To the Editor: A 61-year-old man was hospitalized because ofan unexplained weight loss of 8 kg and fatigue. Eight yearsearlier, he had undergone a total hip arthroplasty on the leftside (with a prosthetic femoral component of titanium and anacetabular shell of polyethylene) because of arthrosis.
The physical examination showed hepatomegaly and splenomegaly.A liver-biopsy specimen showed granulomatous hepatitis associatedwith rare intracytoplasmic dark particles initially misinterpretedas a formalin-pigment artifact. The results of clinical andlaboratory studies ruled out infectious hepatitis, sarcoidosis,prior hepatic or biliary disease, vasculitis, inflammatory colitis,drug-induced hepatitis, and toxic effects of . . . [Full Text of this Article]
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