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Previous Volume 335:1523-1525 November 14, 1996 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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A rare disease can represent irrelevant esoterica to some but an interesting challenge to others — an oddity or an opportunity. Ogden Bruton's observations in a boy with unusual susceptibility to bacterial infections show how clinical acumen and simple technical means led to the discovery of a new disease, agammaglobulinemia.¹ Echoes of Bruton's case report, which appeared 44 years ago, reverberate in this issue of the Journal with the publication of a paper by Yel et al.² on novel and instructive molecular variants of agammaglobulinemia.

Bruton's patient, a four-year-old boy, was first admitted to Walter Reed Army Hospital because of . . . [Full Text of this Article]

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