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Editorial
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Volume 335:1523-1525 November 14, 1996 Number 20
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Agammaglobulinemia and Insights into B-Cell Differentiation

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A rare disease can represent irrelevant esoterica to some but an interesting challenge to others — an oddity or an opportunity. Ogden Bruton's observations in a boy with unusual susceptibility to bacterial infections show how clinical acumen and simple technical means led to the discovery of a new disease, agammaglobulinemia.1 Echoes of Bruton's case report, which appeared 44 years ago, reverberate in this issue of the Journal with the publication of a paper by Yel et al.2 on novel and instructive molecular variants of agammaglobulinemia.

Bruton's patient, a four-year-old boy, was first admitted to Walter Reed Army Hospital because of . . . [Full Text of this Article]

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