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Previous Volume 335:1563-1567 November 21, 1996 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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X-linked severe combined immunodeficiency is a recessive hereditary disease characterized by severe and persistent infections starting in the first months of life and associated with diarrhea and failure to thrive.¹ Affected infants almost invariably present with an absence of T cells and natural killer cells, normal or elevated B-cell counts, and hypogammaglobulinemia. This disease is rapidly fatal without bone marrow transplantation.²

The disease locus has been mapped to Xq12–13,³ and the genetic defect identified as a mutation of the chain of the interleukin-2 receptor,⁴ which has been cloned and was recently renamed the common (c) chain because of its . . . [Full Text of this Article]

Case Report

Methods

Flow Cytometry

Lymphocyte Proliferation

Establishment of B-Cell and T-Cell Lines

DNA Analysis

Results

Immunologic Studies

Studies of the c Chain

Discussion

Source Information

From Universitätskinderklinik, Heinrich-Heine Universität, Düsseldorf, Germany (V.S., V.W., U.D., G.H., H.S.); INSERM Unité 429, Hôpital Necker–Enfants Malades, Paris (F.L.D., A.F., G.S.B.); Bernhard Nocht-Institut, Hamburg, Germany (B.B.); and Institut für Klinische und Molekulare Virologie, Universität Erlangen–Nürnberg, Nuremberg, Germany (I.M.-F.).

Address reprint requests to Dr. Wahn at Heinrich-Heine University Düsseldorf, Department of Pediatrics, Moorenstr. 5, 40225 Düsseldorf, Germany.

References

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