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Previous Volume 335:1570-1580 November 21, 1996 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Primary biliary cirrhosis is a chronic, progressive cholestatic liver disease of unknown cause that usually affects middle-aged women and eventually leads to liver failure and the need for liver transplantation. It is diagnosed more frequently now than it was a decade ago because of its greater recognition by physicians and the widespread use of automated blood testing and the antimitochondrial-antibody test, which is relatively specific for the disease.¹ Important advances have been made in our understanding of the natural history, pathogenesis, and treatment of primary biliary cirrhosis since the subject was last reviewed in the Journal.² Little has changed . . . [Full Text of this Article]

Prevalence, Epidemiology, and Genetics

Pathological Features

Gross Findings

Hepatic Histology

Immunologic Abnormalities

Abnormalities of Humoral Immunity

Abnormalities of Cellular Immunity

Mitochondrial Antigens and Antibodies

Clinical Features

Symptoms and Physical Examination

Laboratory Tests

Diagnosis

Associated Disorders

Natural History and Prognosis

Treatment of Symptoms

Treatment of Underlying Disease

Ursodiol

Cyclosporine

Colchicine

Methotrexate

Liver Transplantation

Source Information

From the Division of Gastroenterology, New England Medical Center, 750 Washington St., Boston, MA 02111, where reprint requests should be addressed to Dr. Kaplan.

References

Related Letters:

Primary Biliary Cirrhosis
Caldwell S. H., Leonhardt U., Näther M., Ramadori G., Kaplan M. M.
Extract | Full Text  
N Engl J Med 1997; 336:1387-1388, May 8, 1997. Correspondence

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