Lymphocytes are equipped to eradicate noxious agents (microbes,cancer cells, and grafts) that disturb the body's equilibrium,but when their cellular activity is excessive, the results areharmful. The list of abnormalities known to be caused by excessivelymphocyte activity is extensive. We review two distinct pathwaysthat account for most of the cellular injury induced by lymphocytes,with an emphasis on their clinical implications.
The Molecular Basis of Lymphocyte-Mediated Cytolysis
Unlike humoral immune responses, which are mediated throughantibodies and complement and can be transferred in serum tounimmunized subjects, cellular immune responses require thedirect participation of effector cells such as T lymphocytes.The . . . [Full Text of this Article]
Perforin–Granzyme-Dependent Cell Killing
Fas-Dependent Cell Killing
The Involvement of Killer Lymphocytes in Immune Protection and Immunopathogenesis
Viral Infections
Intracellular Bacterial and Protozoal Infections
Autoimmune Diseases
Allograft Rejection
Tumor Surveillance
Conclusions
Source Information
From the Laboratory of Molecular Immunology and Cell Biology, Rockefeller University, New York (C.-C.L., J.D.-E Y.), and Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston (L.H.Y.Y.).
Address reprint requests to Dr. Liu at the Laboratory of Molecular Immunology and Cell Biology, Rockefeller University, 1230 York Ave., New York, NY 10021.
References
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Felgar, R. E., Steward, K. R., Cousar, J. B., Macon, W. R.
(1998). T-Cell-Rich Large-B-Cell Lymphomas Contain Non-Activated CD8+ Cytolytic T Cells, Show Increased Tumor Cell Apoptosis, and Have Lower Bcl-2 Expression Than Diffuse Large-B-Cell Lymphomas. Am. J. Pathol.
153: 1707-1715
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Fogler, W. E., Volker, K., Watanabe, M., Wigginton, J. M., Roessler, P., Brunda, M. J., Ortaldo, J. R., Wiltrout, R. H.
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161: 6014-6021
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153: 1377-1381
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