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Previous Volume 335:1740-1748 December 5, 1996 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Chorionic tumors, or gestational trophoblastic diseases, originate from placental tissues and are among the rare human tumors that can be cured even in the presence of widespread metastasis.^1,2,3,4 Gestational trophoblastic diseases include a spectrum of interrelated tumors, including complete and partial hydatidiform mole, placental-site trophoblastic tumor, and choriocarcinoma, that vary in their propensity for local invasion and spreading. Although persistent gestational trophoblastic tumors develop most commonly after a molar pregnancy, they may follow any gestation. This article concentrates on recent advances in the understanding of the pathogenesis, natural history, and treatment of gestational trophoblastic diseases and describes our current approach . . . [Full Text of this Article]

Epidemiology and Risk Factors

Clinical Presentation

Complete Molar Pregnancy

Partial Hydatidiform Molar Pregnancy

Diagnosis of Complete and Partial Molar Pregnancy

Treatment of Molar Pregnancy

Follow-Up after a Molar Pregnancy

Persistent Gestational Trophoblastic Tumors

Nonmetastatic Disease

Metastatic Disease

Anatomical Staging and Prognostic Scoring Systems

Diagnostic Evaluation

            Management

            Stage I Tumor

            Stage II or III Tumor

            Stage IV Tumor

            Follow-Up

            Selection of Chemotherapy

            Single-Agent Chemotherapy

            Combination Chemotherapy

Subsequent Pregnancies

Secondary Tumors

Source Information

From the New England Trophoblastic Disease Center, Division of Gynecologic Oncology, Brigham and Women's Hospital and Dana–Farber Cancer Institute, and the Department of Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School — all in Boston.

Address reprint requests to Dr. Berkowitz at the Division of Gynecologic Oncology, Brigham and Women's Hospital, 75 Francis St., Boston, MA 02115.

References

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