Bone Marrow Transplantation in Severe Combined Immunodeficiency from a Sibling Who Had Received a Paternal Bone Marrow Transplant
E. Richard Stiehm, M.D., Robert L. Roberts, M.D., Ph.D., Jean Hanley-Lopez, M.D., Mary E. Wakim, M.D., Maria G. Pallavicini, Ph.D., Morton J. Cowan, M.D., Robert B. Ettenger, M.D., and Stephen A. Feig, M.D.
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Bone marrow transplantation to treat autosomal recessive severecombined immunodeficiency was undertaken in a one-month-oldgirl. The donor was the patient's HLA-mismatched six-year-oldsister, who had previously received a marrow transplant fromher father that was mismatched with regard to one HLA haplotype,to treat the same condition. The graft in the younger girl wasnot depleted of T cells, and no conditioning regimen was usedbefore transplantation. The prompt engraftment in the girl andher uneventful course after transplantation indicated that thepaternal T cells in the older sister's marrow had acquired immunologictolerance of relevant HLA antigens and . . . [Full Text of this Article]
Case Reports
Patient 1
Patient 2
Discussion
Source Information
From the Department of Pediatrics (E.R.S., R.L.R., J.H.-L., M.E.W., R.B.E., S.A.F.), University of California at Los Angeles, Los Angeles; and the Cancer Center (M.G.P.) and the Department of Pediatrics (M.J.C.), University of California at San Francisco, San Francisco.
Address reprint requests to Dr. Stiehm at UCLA Children's Hospital, Room 22-387 MDCC, 10833 Le Conte Ave., Los Angeles, CA 90095-1752.
References
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Cohen, J. M., Rogers, V., Gaspar, H. B., Jones, A., Davies, E. G., Rao, K., McCloskey, D. J., Gilmour, K., Wynn, R., Amrolia, P. J., Veys, P.
(2006). Serial transplantation of mismatched donor hematopoietic cells between HLA-identical sibling pairs with congenital immunodeficiency: in vivo tolerance permits rapid immune reconstitution following T-replete transplantation without GVHD in the secondary recipient. Blood
108: 2124-2126
[Abstract][Full Text]
Gluckman, E.
(1996). The Therapeutic Potential of Fetal and Neonatal Hematopoietic Stem Cells. NEJM
335: 1839-1840
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