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Correction to Hien et al., N Engl J Med 335(2):76-83 July 11, 1996.

Correspondence
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Volume 335:1922-1924 December 19, 1996 Number 25
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Artemether in Severe Malaria

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by Hien, T. T.
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by van Hensbroek, M. B.
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by Hien, T. T.
To the Editor: Boele van Hensbroek et al. and Hien et al. (July 11 issue)1,2 conclude that artemether is a safe and effective alternative to quinine in the treatment of severe malaria. Curiously, the data in the two reports do not fully support this optimistic conclusion. In both studies the clearance of parasites was more rapid with artemether, but coma was significantly prolonged, with longer hospitalization, at least among Vietnamese adults. We have also observed such a discrepancy between the course of parasitemia and the patient's clinical condition,3 which may be related to the persistence of mature parasites in the . . . [Full Text of this Article]

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