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Previous Volume 335:1924-1925 December 19, 1996 Number 25 Next

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To the Editor: Acquired alveolar proteinosis is a rare lung disease of adults characterized by excessive accumulation of surfactant.¹ Standard therapy is whole-lung lavage, which usually provides temporary symptomatic benefit.¹ In mice lacking the hematopoietic regulator granulocyte–macrophage colony-stimulating factor (GM-CSF), a pulmonary abnormality develops that resembles alveolar proteinosis.^2,3 Therefore, we initiated a trial of recombinant human GM-CSF therapy in a patient with this disease after obtaining the approval of the institutional ethics committee and written informed consent from the patient.

A 49-year-old man was given a diagnosis of alveolar proteinosis after open-lung biopsy in 1993. He subsequently underwent three therapeutic . . . [Full Text of this Article]

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