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Previous Volume 335:157-166 July 18, 1996 Number 3 Next

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ABSTRACT

Background Transplantation of bone marrow from unrelated donors is limited by a lack of HLA-matched donors and the risk of graft-versus-host disease (GVHD). Placental blood from sibling donors can reconstitute hematopoiesis. We report preliminary results of transplantation using partially HLA-mismatched placental blood from unrelated donors.

Methods Twenty-five consecutive patients, primarily children, with a variety of malignant and nonmalignant conditions received placental blood from unrelated donors and were evaluated for hematologic and immunologic reconstitution and GVHD. HLA matching was performed before transplantation by serologic typing for class I HLA antigens and low-resolution molecular typing for class II HLA alleles. In donor–recipient pairs who differed by no more than one HLA antigen or allele, high-resolution class II HLA typing was done retrospectively. For donor–recipient pairs who were mismatched for two HLA antigens or alleles, high-resolution typing was used prospectively to select the best match for HLA-DRB1.

Results Twenty-four of the 25 donor–recipient pairs were discordant for one to three HLA antigens. In 23 of the 25 transplant recipients, the infused hematopoietic stem cells engrafted. Acute grade III GVHD occurred in 2 of the 21 patients who could be evaluated, and 2 patients had chronic GVHD. In vitro proliferative responses of T cells and B cells to plant mitogens were detected 60 days after transplantation. With a median follow-up of 12¹ /2 months and a minimal follow-up of 100 days, the overall 100-day survival rate among these patients was 64 percent, and the overall event-free survival was 48 percent.

Conclusions HLA-mismatched placental blood from unrelated donors is an alternative source of stem cells for hematopoietic reconstitution in children.

Source Information

From the Pediatric Bone Marrow Transplant Program at Duke University Medical Center, Durham, N.C. (J.K., M.L., M.L.G., C.S., J.F.O., E.C.H., G.C.), and the Placental Blood Program at the New York Blood Center, New York (C.C., C.E.S., P.R.).

Address reprint requests to Dr. Kurtzberg at Box 3350, Duke University Medical Center, Durham, NC 27710.

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Placental-Blood Transplantation
Ammann A. J., Bertolini F., della Cuna G. R., Locatelli F., Maccario R., Zecca M., Abecasis M. M., Guimaraes A., Machado A., Kurtzberg J., Rubenstein P., Stevens C. E., Jefferies L. C., Silberstein L. E.
Extract | Full Text  
N Engl J Med 1997; 336:68-70, Jan 2, 1997. Correspondence

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• Barker, J. N., Davies, S. M., DeFor, T., Ramsay, N. K. C., Weisdorf, D. J., Wagner, J. E. (2001). Survival after transplantation of unrelated donor umbilical cord blood is comparable to that of human leukocyte antigen-matched unrelated donor bone marrow: results of a matched-pair analysis. Blood 97: 2957-2961 [Abstract] [Full Text]  
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• Thomson, B. G., Robertson, K. A., Gowan, D., Heilman, D., Broxmeyer, H. E., Emanuel, D., Kotylo, P., Brahmi, Z., Smith, F. O. (2000). Analysis of engraftment, graft-versus-host disease, and immune recovery following unrelated donor cord blood transplantation. Blood 96: 2703-2711 [Abstract] [Full Text]  
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• Davis, B. R., Yannariello-Brown, J., Prokopishyn, N. L., Luo, Z., Smith, M. R., Wang, J., Carsrud, N. D. V., Brown, D. B. (2000). Glass needle-mediated microinjection of macromolecules and transgenes into primary human blood stem/progenitor cells. Blood 95: 437-444 [Abstract] [Full Text]  
• Sullivan, K. M., Parkman, R., Walters, M. C. (2000). Bone Marrow Transplantation for Non-Malignant Disease. ASH Education Book 2000: 319-338 [Abstract] [Full Text]  
• Verhasselt, B., Kerre, T., Naessens, E., Vanhecke, D., De Smedt, M., Vandekerckhove, B., Plum, J. (1999). Thymic Repopulation by CD34+ Human Cord Blood Cells After Expansion in Stroma-Free Culture. Blood 94: 3644-3652 [Abstract] [Full Text]  
• Kadereit, S., Mohammad, S. F., Miller, R. E., Woods, K. D., Listrom, C. D., McKinnon, K., Alali, A., Bos, L. S., Iacobucci, M. L., Sramkoski, M. R., Jacobberger, J. W., Laughlin, M. J. (1999). Reduced NFAT1 Protein Expression in Human Umbilical Cord Blood T Lymphocytes. Blood 94: 3101-3107 [Abstract] [Full Text]  
• Work Group on Cord Blood Banking, (1999). Cord Blood Banking for Potential Future Transplantation: Subject Review. Pediatrics 104: 116-118 [Abstract] [Full Text]  
• Felix, C. A., Lange, B. J. (1999). Leukemia in Infants. The Oncologist 4: 225-240 [Abstract] [Full Text]  
• Locatelli, F., Rocha, V., Chastang, C., Arcese, W., Michel, G., Abecasis, M., Messina, C., Ortega, J., Badell-Serra, I., Plouvier, E., Souillet, G., Jouet, J.-P., Pasquini, R., Ferreira, E., Garnier, F., Gluckman, E. (1999). Factors Associated With Outcome After Cord Blood Transplantation in Children With Acute Leukemia. Blood 93: 3662-3671 [Abstract] [Full Text]  
• Sorg, R. V., Kogler, G., Wernet, P. (1999). Identification of Cord Blood Dendritic Cells as an Immature CD11c- Population. Blood 93: 2302-2307 [Abstract] [Full Text]  
• Buckley, R. H., Schiff, S. E., Schiff, R. I., Markert, M. L., Williams, L. W., Roberts, J. L., Myers, L. A., Ward, F. E. (1999). Hematopoietic Stem-Cell Transplantation for the Treatment of Severe Combined Immunodeficiency. NEJM 340: 508-516 [Abstract] [Full Text]  
• Guenechea, G., Segovia, J.C., Albella, B., Lamana, M., Ramirez, M., Regidor, C., Fernandez, M.N., Bueren, J.A. (1999). Delayed Engraftment of Nonobese Diabetic/Severe Combined Immunodeficient Mice Transplanted With Ex Vivo-Expanded Human CD34+ Cord Blood Cells. Blood 93: 1097-1105 [Abstract] [Full Text]  
• WILL, A M (1999). Umbilical cord blood transplantation. Arch. Dis. Child. 80: 3-6 [Full Text]  
• Tezcan, I., Xu, W., Gurgey, A., Tuncer, M., Cetin, M., Oner, C., Yetgin, S., Ersoy, F., Aizencang, G., Astrin, K.H., Desnick, R.J. (1998). Congenital Erythropoietic Porphyria Successfully Treated by Allogeneic Bone Marrow Transplantation. Blood 92: 4053-4058 [Abstract] [Full Text]  
• Rubinstein, P., Carrier, C., Scaradavou, A., Kurtzberg, J., Adamson, J., Migliaccio, A. R., Berkowitz, R. L., Cabbad, M., Dobrila, N. L., Taylor, P. E., Rosenfield, R. E., Stevens, C. E. (1998). Outcomes among 562 Recipients of Placental-Blood Transplants from Unrelated Donors. NEJM 339: 1565-1577 [Abstract] [Full Text]  
• Parkman, R. (1998). The Future of Placental-Blood Transplantation. NEJM 339: 1628-1629 [Full Text]  
• de La Selle, V., Gluckman, E., Bruley-Rosset, M. (1998). Graft-Versus-Host Disease and Graft-Versus-Leukemia Effect in Mice Grafted With Peripheral Newborn Blood. Blood 92: 3968-3975 [Abstract] [Full Text]  
• Frostad, S., Bjerknes, R., Abrahamsen, J.F., Olweus, J., Bruserud, O. (1998). Insulin-Like Growth Factor-1 (IGF-1) has a Costimulatory Effect on Proliferation of Committed Progenitors Derived from Human Umbilical Cord CD34+ Cells. Stem Cells 16: 334-342 [Abstract] [Full Text]  
• Tisdale, J.F., Hanazono, Y., Sellers, S.E., Agricola, B.A., Metzger, M.E., Donahue, R.E., Dunbar, C.E. (1998). Ex Vivo Expansion of Genetically Marked Rhesus Peripheral Blood Progenitor Cells Results in Diminished Long-Term Repopulating Ability. Blood 92: 1131-1141 [Abstract] [Full Text]  
• Mao, M., Fu, G., Wu, J.-S., Zhang, Q.-H., Zhou, J., Kan, L.-X., Huang, Q.-H., He, K.-L., Gu, B.-W., Han, Z.-G., Shen, Y., Gu, J., Yu, Y.-P., Xu, S.-H., Wang, Y.-X., Chen, S.-J., Chen, Z. (1998). Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. Proc. Natl. Acad. Sci. USA 95: 8175-8180 [Abstract] [Full Text]  
• Chalmers, I.M.H., Janossy, G., Contreras, M., Navarrete, C. (1998). Intracellular Cytokine Profile of Cord and Adult Blood Lymphocytes. Blood 92: 11-18 [Abstract] [Full Text]  
• Orlic, D., Girard, L. J., Anderson, S. M., Pyle, L. C., Yoder, M. C., Broxmeyer, H. E., Bodine, D. M. (1998). Identification of Human and Mouse Hematopoietic Stem Cell Populations Expressing High Levels of mRNA Encoding Retrovirus Receptors. Blood 91: 3247-3254 [Abstract] [Full Text]  
• Krivit, W., Shapiro, E. G., Peters, C., Wagner, J. E., Cornu, G., Kurtzberg, J., Wenger, D. A., Kolodny, E. H., Vanier, M. T., Loes, D. J., Dusenbery, K., Lockman, L. A. (1998). Hematopoietic Stem-Cell Transplantation in Globoid-Cell Leukodystrophy. NEJM 338: 1119-1127 [Abstract] [Full Text]  
• Porcu, P., Gaddy, J., Broxmeyer, H. E. (1998). Alloantigen-induced unresponsiveness in cord blood T lymphocytes is associated with defective activation of Ras. Proc. Natl. Acad. Sci. USA 95: 4538-4543 [Abstract] [Full Text]  
• Timeus, F., Crescenzio, N., Basso, G., Ramenghi, U., Saracco, P., Gabutti, V. (1998). Cell Adhesion Molecule Expression in Cord Blood CD34+ Cells. Stem Cells 16: 120-126 [Abstract] [Full Text]  
• Gardiner, C. M., Meara, A. O', Reen, D. J. (1998). Differential Cytotoxicity of Cord Blood and Bone Marrow-Derived Natural Killer Cells. Blood 91: 207-213 [Abstract] [Full Text]  
• Garderet, L., Dulphy, N., Douay, C., Chalumeau, N., Schaeffer, V., Zilber, M.-T., Lim, A., Even, J., Mooney, N., Gelin, C., Gluckman, E., Charron, D., Toubert, A. (1998). The Umbilical Cord Blood alpha beta T-Cell Repertoire: Characteristics of a Polyclonal and Naive but Completely Formed Repertoire. Blood 91: 340-346 [Abstract] [Full Text]  
• Cairo, M. S., Wagner, J. E. (1997). Placental and/or Umbilical Cord Blood: An Alternative Source of Hematopoietic Stem Cells for Transplantation. Blood 90: 4665-4678 [Full Text]  
• Qian, J. X., Lee, S. m., Suen, Y., Knoppel, E., van de Ven, C., Cairo, M. S. (1997). Decreased Interleukin-15 From Activated Cord Versus Adult Peripheral Blood Mononuclear Cells and the Effect of Interleukin-15 in Upregulating Antitumor Immune Activity and Cytokine Production in Cord Blood. Blood 90: 3106-3117 [Abstract] [Full Text]  
• D'Andrea, A. D., Grompe, M. (1997). Molecular Biology of Fanconi Anemia: Implications for Diagnosis and Therapy. Blood 90: 1725-1736 [Full Text]  
• Gluckman, E., Rocha, V., Boyer-Chammard, A., Locatelli, F., Arcese, W., Pasquini, R., Ortega, J., Souillet, G., Ferreira, E., Laporte, J.-P., Fernandez, M., Chastang, C., The Eurocord Transplant Group and the European Blo, (1997). Outcome of Cord-Blood Transplantation from Related and Unrelated Donors. NEJM 337: 373-381 [Abstract] [Full Text]  
• Wang, J. C.Y., Doedens, M., Dick, J. E. (1997). Primitive Human Hematopoietic Cells Are Enriched in Cord Blood Compared With Adult Bone Marrow or Mobilized Peripheral Blood as Measured by the Quantitative In Vivo SCID-Repopulating Cell Assay. Blood 89: 3919-3924 [Abstract] [Full Text]  
• Henslee-Downey, P. J., Abhyankar, S. H., Parrish, R. S., Pati, A. R., Godder, K. T., Neglia, W. J., Goon-Johnson, K. S., Geier, S. S., Lee, C. G., Gee, A. P. (1997). Use of Partially Mismatched Related Donors Extends Access to Allogeneic Marrow Transplant. Blood 89: 3864-3872 [Abstract] [Full Text]  
• Bertolini, F., Battaglia, M., Pedrazzoli, P., Antonio Da Prada, G., Lanza, A., Soligo, D., Caneva, L., Sarina, B., Murphy, S., Thomas, T., Robustelli della Cuna, G. (1997). Megakaryocytic Progenitors Can Be Generated Ex Vivo and Safely Administered to Autologous Peripheral Blood Progenitor Cell Transplant Recipients. Blood 89: 2679-2688 [Abstract] [Full Text]  
• Rottman, G. A., Ramirez, M., Civin, C. I. (1997). Cord Blood Transplantation: A Promising Future. Pediatrics 99: 475-475 [Full Text]  
• Lie, A. K.W., To, L. B. (1997). Peripheral Blood Stem Cells: Transplantation and Beyond. The Oncologist 2: 40-49 [Abstract] [Full Text]  
• Ammann, A. J., Bertolini, F., della Cuna, G. R., Locatelli, F., Maccario, R., Zecca, M., Abecasis, M. M., Guimaraes, A., Machado, A., Kurtzberg, J., Rubenstein, P., Stevens, C. E., Jefferies, L. C., Silberstein, L. E. (1997). Placental-Blood Transplantation. NEJM 336: 68-70 [Full Text]  
• Forte, K. J. (1997). Alternative Donor Sources in Pediatric Bone Marrow Transplantation. Journal of Pediatric Oncology Nursing 14: 213-224 [Abstract]  
• Gluckman, E. (1996). The Therapeutic Potential of Fetal and Neonatal Hematopoietic Stem Cells. NEJM 335: 1839-1840 [Full Text]  
• Silberstein, L. E., Jefferies, L. C. (1996). Placental-Blood Banking -- A New Frontier in Transfusion Medicine. NEJM 335: 199-201 [Full Text]