FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 335:167-170 July 18, 1996 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

To circumvent the problems inherent in allogeneic bone marrow transplantation, allogeneic cord blood has been studied as an alternative source of hematopoietic stem cells. Preliminary results with cord blood from an HLA-matched sibling are encouraging, but the experience with this procedure is limited.^1,2,3,4,5 Although some 200 transplantations of cord blood have been performed in children,^6,7 few have been performed in adults. We describe an adult with chronic myelogenous leukemia who underwent the transplantation of cord-blood stem cells successfully.

Case Report

A 26-year-old woman was found to have chronic myelogenous leukemia in July 1990. All the leukemic cells had the Philadelphia chromosome, and . . . [Full Text of this Article]

Methods

Hematopoietic Progenitor Assay

Immunophenotypic Analysis

Fluorescence in Situ Hybridization

PCR to Detect Chimeric BCR-ABL mRNA

Results

Discussion

Source Information

From the Department of Hematology (J.-P.L., N.-C.G., S.L., A.N.), the Laboratory of Cytogenetics (M.-F.P.), and the Department of Biochemistry B (V.B.), Hôpital St. Antoine, Paris; the Formation Associée Claude Bernard Unité de Recherche sur les Greffes de Cellules Souches Hématopoiétiques, Faculté de Médecine St. Antoine, Paris (J.-P.L., N.-C.G., V.B., M.L., L.D., A.N.); and the Laboratory of Immunogenetics, New York Blood Center, New York (P.R.).

Address reprint requests to Professor Gorin at Hôpital St. Antoine, 184, rue du Faubourg St. Antoine, 75012 Paris, France.

References

This article has been cited by other articles:

• Sanz, G. F., Saavedra, S., Planelles, D., Senent, L., Cervera, J., Barragan, E., Jimenez, C., Larrea, L., Martin, G., Martinez, J., Jarque, I., Moscardo, F., Plume, G., Andreu, R., Regadera, A. I., Garcia, I., Molla, S., Solves, P., de la Rubia, J., Bolufer, P., Benlloch, L., Soler, M. A., Marty, M. L., Sanz, M. A. (2001). Standardized, unrelated donor cord blood transplantation in adults with hematologic malignancies. Blood 98: 2332-2338 [Abstract] [Full Text]  
• Laughlin, M. J., Barker, J., Bambach, B., Koc, O. N., Rizzieri, D. A., Wagner, J. E., Gerson, S. L., Lazarus, H. M., Cairo, M., Stevens, C. E., Rubinstein, P., Kurtzberg, J. (2001). Hematopoietic Engraftment and Survival in Adult Recipients of Umbilical-Cord Blood from Unrelated Donors. NEJM 344: 1815-1822 [Abstract] [Full Text]  
• Frostad, S., Bjerknes, R., Abrahamsen, J.F., Olweus, J., Bruserud, O. (1998). Insulin-Like Growth Factor-1 (IGF-1) has a Costimulatory Effect on Proliferation of Committed Progenitors Derived from Human Umbilical Cord CD34+ Cells. Stem Cells 16: 334-342 [Abstract] [Full Text]  
• Hehlmann, R. (1998). A Chance of Cure for Every Patient with Chronic Myeloid Leukemia?. NEJM 338: 980-982 [Full Text]  
• Cairo, M. S., Wagner, J. E. (1997). Placental and/or Umbilical Cord Blood: An Alternative Source of Hematopoietic Stem Cells for Transplantation. Blood 90: 4665-4678 [Full Text]  
• Lie, A. K.W., To, L. B. (1997). Peripheral Blood Stem Cells: Transplantation and Beyond. The Oncologist 2: 40-49 [Abstract] [Full Text]  
• Silberstein, L. E., Jefferies, L. C. (1996). Placental-Blood Banking -- A New Frontier in Transfusion Medicine. NEJM 335: 199-201 [Full Text]