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Previous Volume 335:207-208 July 18, 1996 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Reiman et al. (March 21 issue)¹ conclude that abnormalities in glucose metabolism, evaluated by positron-emission tomography (PET) in asymptomatic subjects homozygous for the 4 allele for apolipoprotein E, provide preclinical evidence of Alzheimer's disease. The 4 allele is highly prevalent not only in patients with Alzheimer's disease but also in those with atherosclerotic vascular disease, including ischemic cerebrovascular disease and vascular dementia.^2-4 The PET abnormalities cannot be used to distinguish vascular dementia (formerly called multi-infarct dementia) from Alzheimer's disease.^5,6 Thus, apolipoprotein E genotyping, PET, or the two combined may not be reliable tools for confidently diagnosing presymptomatic . . . [Full Text of this Article]

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