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Previous Volume 335:289-290 July 25, 1996 Number 4 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Mandel et al. (March 21 issue)¹ suggest that contributing factors, such as resistance to activated protein C, may be needed for thrombosis to occur in patients with moderate increases in plasma levels of homocysteine. However, isolated hyperhomocysteinemia after fasting or a methionine load has been identified as an independent risk factor for venous thrombosis in two studies of patients with early-onset venous or arterial thromboembolic disease (or both),^2,3 and isolated hyperhomocysteinemia after fasting is a proven risk factor for deep-vein thrombosis in the general population.⁴ Because of the high prevalence of both resistance to activated protein C . . . [Full Text of this Article]

References

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• Ueland, P. M, Refsum, H., Beresford, S. A., Vollset, S. E. (2000). The controversy over homocysteine and cardiovascular risk. Am. J. Clin. Nutr. 72: 324-332 [Abstract] [Full Text]  
• Gaustadnes, M., Rudiger, N., Rasmussen, K., Ingerslev, J. (2000). Familial Thrombophilia Associated With Homozygosity for the Cystathionine {beta}-Synthase 833T->C Mutation. Arterioscler. Thromb. Vasc. Bio. 20: 1392-1395 [Abstract] [Full Text]  
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