Dementia is the clinical syndrome characterized by acquiredlosses of cognitive and emotional abilities severe enough tointerfere with daily functioning and the quality of life. Theterm does not imply a specific cause or pathologic process.More than 55 illnesses, some nonprogressive, can cause dementia.1It occurs primarily late in life; the prevalence is about 1percent at the age of 60 years and doubles every five years,to reach 30 to 50 percent by the age of 85.2,3
Because all types of dementia are treatable, at least with psychosocialinterventions, accurate diagnosis is essential to determinethe appropriate . . . [Full Text of this Article]
Clinical Approach
Clinical Features of Common Types of Dementia
Alzheimer's Disease
Cognitive Decline
Noncognitive Symptoms
Changes in the Neurologic Status
Vascular Dementia
Pick's Disease and Dementia of the Frontal-Lobe Type
Dementia with Parkinsonism
CreutzfeldtJakob Disease
Hydrocephalus
Differential Diagnosis and Initial Management
Conclusions
Source Information
From the University Alzheimer Center, University Hospitals of Cleveland, and the Department of Neurology, Case Western Reserve University School of Medicine, Cleveland.
Address reprint requests to Dr. Geldmacher at 12200 Fairhill Rd., Cleveland, OH 44120.
References
Related Letters:
Evaluation of Suspected Dementia
Roses A. D., Saunders A. M., Charness M. E., Rubinstein M., Denays R., Collier A., Vanneste J., Lazzara E. W., Whitehouse P. J., Geldmacher D. S.
Extract |
Full Text
N Engl J Med 1996;
335:1996-1998, Dec 26, 1996.
Correspondence
Megaloblastosis
Carr J. M., Raya J. M., Lowenthal M. N., Moll S.
Extract |
Full Text
N Engl J Med 1996;
335:2000-2001, Dec 26, 1996.
Correspondence
This article has been cited by other articles:
Dhoat, S., Ali, K., Bulpitt, C. J., Rajkumar, C.
(2008). Vascular compliance is reduced in vascular dementia and not in Alzheimer's disease. Age Ageing
37: 653-659
[Abstract][Full Text]
Dickerson, B. C., Holtzman, D., Grant, P. E., Tian, D.
(2005). Case 36-2005 -- A 61-Year-Old Woman with Seizure, Disturbed Gait, and Altered Mental Status.. NEJM
353: 2271-2280
[Full Text]
Luchsinger, J. A., Tang, M.-X., Shea, S., Mayeux, R.
(2003). Antioxidant Vitamin Intake and Risk of Alzheimer Disease. Arch Neurol
60: 203-208
[Abstract][Full Text]
Luchsinger, J. A., Tang, M.-X., Stern, Y., Shea, S., Mayeux, R.
(2001). Diabetes Mellitus and Risk of Alzheimer's Disease and Dementia with Stroke in a Multiethnic Cohort. Am J Epidemiol
154: 635-641
[Abstract][Full Text]
Landi, F., Onder, G., Cattel, C., Gambassi, G., Lattanzio, F., Cesari, M., Russo, A., Bernabei, R.
(2001). Functional Status and Clinical Correlates in Cognitively Impaired Community-Living Older People. J Geriatr Psychiatry Neurol
14: 21-27
[Abstract]
Gifford, D. R., Holloway, R. G., Vickrey, B. G.
(2000). Systematic Review of Clinical Prediction Rules for Neuroimaging in the Evaluation of Dementia. Arch Intern Med
160: 2855-2862
[Abstract][Full Text]
Tagliati, M., Perl, D. P, Drayer, B., Olanow, C W.
(2000). Progressive dementia and gait disorder in a 78 year old woman. J. Neurol. Neurosurg. Psychiatry
68: 526-531
[Full Text]
Guo, Z., Fratiglioni, L., Zhu, L., Fastbom, J., Winblad, B., Viitanen, M.
(1999). Occurrence and Progression of Dementia in a Community Population Aged 75 Years and Older: Relationship of Antihypertensive Medication Use. Arch Neurol
56: 991-996
[Abstract][Full Text]
Richards, S. S., Hendrie, H. C.
(1999). Diagnosis, Management, and Treatment of Alzheimer Disease: A Guide for the Internist. Arch Intern Med
159: 789-798
[Abstract][Full Text]
Roses, A. D., Saunders, A. M., Charness, M. E., Rubinstein, M., Denays, R., Collier, A., Vanneste, J., Lazzara, E. W., Whitehouse, P. J., Geldmacher, D. S.
(1996). Evaluation of Suspected Dementia. NEJM
335: 1996-1998
[Full Text]
Carr, J. M., Raya, J. M., Lowenthal, M. N., Moll, S.
(1996). Megaloblastosis. NEJM
335: 2000-2001
[Full Text]