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Correspondence
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Volume 335:352-355 August 1, 1996 Number 5
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Late Effects of Treatment for Childhood Hodgkin's Disease

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 by Donaldson, S. S.
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 by Bhatia, S.
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To the Editor: Bhatia et al. (March 21 issue)1 make the unwarranted statement that radiation, but not chemotherapy, increases the risk of solid tumors, especially breast tumors, in patients treated for childhood Hodgkin's disease.

In the study cohort, only 8 percent of the patients received chemotherapy alone; 23 percent received radiation alone. The remainder received both, but to compare the risks of treatments, only the patients receiving one or the other are appropriate for the analysis. Only one patient in the group receiving chemotherapy alone had a solid tumor, but since the expected number of cases was less than one, . . . [Full Text of this Article]

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