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Correspondence
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Volume 335:355 August 1, 1996 Number 5
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Cryoglobulinemia after Hepatitis B Vaccination

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To the Editor: Vaccination with hepatitis B recombinant vaccine has few serious side effects1 (about 1 per 100,000 doses administered). Some cases of vasculitis have been reported.2 We report two cases of vasculitis with cryoglobulinemia after vaccination against hepatitis B.

A previously healthy, 18-year-old woman who was not taking any medication on a regular basis received a first dose of hepatitis B recombinant vaccine (GenHevac, Pasteur Vaccines) in March 1995 and a second dose in April 1995. Ten days after she received the second dose, painful necrotic and bullous purpura of the legs, suggestive of cutaneous vasculitis, developed. The lesion . . . [Full Text of this Article]

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