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A previously healthy, 18-year-old woman who was not taking any medication on a regular basis received a first dose of hepatitis B recombinant vaccine (GenHevac, Pasteur Vaccines) in March 1995 and a second dose in April 1995. Ten days after she received the second dose, painful necrotic and bullous purpura of the legs, suggestive of cutaneous vasculitis, developed. The lesion
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