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Figure 1. Three large Negri bodies, which are eosinophilic viral inclusion bodies, can be seen in the cytoplasm of a cerebellar Purkinje cell obtained at autopsy from an eight-year-old boy in Mexico City (hematoxylin and eosin, x2300). These viral inclusions are the pathological hallmark of rabies. The boy, bitten on the forearm by a dog that died of rabies 15 days later, had numbness and tingling at the site of the bite several days later. He presented at a clinic one month after the bite, and rabies vaccination with Fuenzalida vaccine (suckling-mouse-brain vaccine) was initiated. Two days later . . . [Full Text of this Article] |