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-agonists in a controlled setting among patients with mild asthma. We fear, however, that this result may create a false sense of security among patients and their physicians that could be conducive to the inappropriate use of these very effective bronchodilators. We would like to remind readers that our long-term epidemiologic studies have shown that the excessive use of
-agonists is associated with a very high risk of fatal or near-fatal asthma 2 and that the threshold of safety is References
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