The Management of Hypertrophic Cardiomyopathy

doi:10.1056/NEJM199703133361107

Volume 336:775-785		March 13, 1997		Number 11

The Management of Hypertrophic Cardiomyopathy

Paolo Spirito, M.D., Christine E. Seidman, M.D., William J. McKenna, M.D., and Barry J. Maron, M.D.

Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Hypertrophic cardiomyopathy is a complex cardiac disease withunique pathophysiologic characteristics and a great diversityof morphologic, functional, and clinical features.¹^,²^,³^,⁴^,⁵^,⁶^,⁷^,⁸The heterogeneity of the disease is accentuated by the factthat it afflicts patients of all ages. During the past few years,technological developments in implantable defibrillators andpacemakers have provided new therapeutic options for patientswith the disease.⁹^,¹⁰^,¹¹^,¹²^,¹³^,¹⁴^,¹⁵^,¹⁶^,¹⁷^,¹⁸ In addition, rapidadvances in our knowledge of the molecular defects responsiblefor hypertrophic cardiomyopathy have deepened our understandingof the disorder and have suggested new approaches to the assessmentof prognosis.¹⁹^,²⁰^,²¹^,²² These recent developments, however,have also generated considerable . . . [Full Text of this Article]

Heterogeneity of Clinical and Genetic Features

Treatment of the Symptoms of Heart Failure

Medical Therapy

Pharmacologic Options

Strategies for Drug Therapy

Treatment of Asymptomatic Patients and Prevention of Disease Progression

Management of Atrial Fibrillation

Treatment Options after the Failure of Drug Therapy

Surgery for Relief of Outflow Tract Obstruction and Symptoms

Nonsurgical Techniques for Relief of Outflow Tract Obstruction and Symptoms

Stratification of Risk

Clinical Indicators of Risk

Major Risk Factors

Electrophysiologic Testing

Syncope

Massive Left Ventricular Hypertrophy

Genetic Indicators of Risk

Prevention of Sudden Death

Amiodarone

Implantable Defibrillators

Source Information

From the Servizio di Cardiologia, Ospedale Sant'Andrea, La Spezia, Italy (P.S.); the Howard Hughes Medical Institute and the Cardiovascular Division, Brigham and Women's Hospital, Boston (C.E.S.); the Department of Cardiological Sciences, St. George's Hospital Medical School, London (W.J.M.); and the Minneapolis Heart Institute Foundation, Minneapolis (B.J.M.).

Address reprint requests to Dr. Spirito at the Servizio di Cardiologia, Ospedale Sant'Andrea, Via Veneto 197, La Spezia 19100, Italy.

References

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The Management of Hypertrophic Cardiomyopathy
Seggewiss H., Gleichmann U., Faber L., Maron B. J., Spirito P., McKenna W. J., Seidman C. E.
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N Engl J Med 1997; 337:349-350, Jul 31, 1997. Correspondence

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