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We stand at a pivotal moment in the history of human experimentation. Long-standing suspicions about research are fading, along with an unconditional commitment to informed consent. The distinction between investigation and therapy is blurring; fears about using subjects as guinea pigs are being superseded by a belief that investigational drugs deliver miracle cures. These attitudes originated with AIDS and have spread to almost all diseases with no known cure, including Alzheimer's disease and cancer. In a manner consistent with this orientation, the Food and Drug Administration's drug-approval procedures have been streamlined, there is a new emphasis on enrolling women in
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