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Review Article
Current Concepts
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Volume 336:933-938 March 27, 1997 Number 13
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Erythropoietin Therapy
Lawrence T. Goodnough, M.D., Terri G. Monk, M.D., and Gerald L. Andriole, M.D.

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Despite impressive advances in the safety of the blood supply,1 the search for therapeutic alternatives to blood continues.2,3 Erythropoietin (along with iron, vitamin B12, and folic acid) has been recommended as a specific medication "that should be used instead of blood transfusion if the clinical condition of the patient permits sufficient time for these agents to promote erythropoiesis."4 Therapy with recombinant human erythropoietin (Epogen, Amgen, Thousand Oaks, Calif.) was first shown to correct the anemia caused by chronic renal failure in patients undergoing dialysis.5 Subsequently, erythropoietin (Procrit, OrthoBiotech, Raritan, N.J.) was also approved for the treatment of anemia caused . . . [Full Text of this Article]

Facilitating the Procurement of Autologous Blood

Erythropoietin

Acute Normovolemic Hemodilution

Combination Therapy

Stimulation of Erythropoiesis without Autologous Blood Donation

Dosage and Cost of Erythropoietin

Improving Cost Effectiveness

Predicting Perioperative Blood Requirements

Conclusions


Source Information

From the Departments of Medicine and Pathology (L.T.G.), Anesthesia (T.G.M.), and Surgery (G.L.A.), Washington University School of Medicine, St. Louis.

Address reprint requests to Dr. Goodnough at the Division of Laboratory Medicine, Box 8118, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110.

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