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Editorial
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Volume 336:949-950 March 27, 1997 Number 13
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Neoplasms and Transplantation — Trading Swords for Plowshares

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The recent death of former U.S. Senator Paul Tsongas at the age of 55 from complications of bone marrow transplantation was a reminder that we have not cleared this treatment of its most difficult problems. The senator had received two marrow transplants — an autograft in 1986 to treat lymphoma, and an allograft in 1996 to treat the myelodysplastic syndrome that was caused by the therapy he had received 10 years earlier.

Secondary neoplasms are well-recognized complications of bone marrow grafts and solid-organ allografts. However, the tumors differ in kind and pathogenesis in the two groups of recipients. The neoplasms . . . [Full Text of this Article]

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